炎症
脂肪因子
脂肪组织
生物信息学
肥胖
计算生物学
机制(生物学)
生物
生物化学
化学
医学
免疫学
内分泌学
瘦素
认识论
哲学
作者
Amanda Fernandes de Medeiros,Jaluza Luana Carvalho de Queiroz,Bruna Leal Lima Maciel,Ana Heloneida de Araújo Morais
出处
期刊:Nutrients
[MDPI AG]
日期:2022-02-06
卷期号:14 (3): 690-690
被引量:10
摘要
Chronic low-grade inflammation is present in overweight and obesity, causing changes in several metabolic pathways. It impairs systemic functioning and positively feeds back the accumulation of more adipose tissue. Studies with hydrolyzed proteins and plant peptides have demonstrated a potential anti-inflammatory and immunomodulatory effect of these peptides. However, it is challenging and necessary to explore the mechanism of action of such molecules because understanding their effects depends on their structural characterizations. Furthermore, the structure might also give insights into safety, efficacy and efficiency, with a view of a possible health application. Thus, the present narrative review aimed to discuss the mechanisms of action of hydrolyzed proteins and plant peptides as anti-inflammatory agents in obesity. Keywords and related terms were inserted into databases for the search. Based on the studies evaluated, these biomolecules act by different pathways, favoring the reduction of inflammatory cytokines and adipokines and the polarization of macrophages to the M2 phenotype. Finally, as a future perspective, bioinformatics is suggested as a tool to help understand and better use these molecules considering their applicability in pre-clinical and clinical studies.
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