胶体金
材料科学
纳米颗粒
体内
壳聚糖
选区衍射
Zeta电位
卵磷脂
结合
粒径
动态光散射
核化学
纳米技术
透射电子显微镜
化学
色谱法
有机化学
物理化学
数学分析
生物技术
数学
生物
作者
Salma A. Fereig,Ghada M. El-Zaafarany,Mona G. Arafa,Mona M.A. Abdel-Mottaleb
出处
期刊:Drug Delivery
[Informa]
日期:2022-05-30
卷期号:29 (1): 1726-1742
被引量:11
标识
DOI:10.1080/10717544.2022.2081383
摘要
Gold nanoparticles are a promising drug delivery system for treatment of inflammatory skin conditions, including psoriasis, due to their small size and anti-inflammatory properties. The aim of this study was to conjugate gold nanoparticles with anti-psoriatic formulations that previously showed successful results in the treatment of psoriasis (tacrolimus-loaded chitosan nanoparticles and lecithin–chitosan nanoparticles) by virtue of their surface charges, then examine whether the hybridization with gold nanoparticles would enhance the anti-psoriatic efficacy in vivo. Successful formation of gold nanoparticles was examined by elemental mapping and selected area electron diffraction (SAED). Hybrid conjugates were examined in terms of particle size and zeta potential by dynamic light scattering (DLS). Morphological features were captured by transmission electron microscope (TEM) and X-ray diffraction (XRD) analysis was conducted, as well. All characterization was conducted for the conjugated nanoparticles and compared with their bare counterparts. The in vivo results on imiquimod (IMQ)-induced mouse model showed promising anti-psoriatic effects upon application of gold conjugated tacrolimus-loaded lecithin–chitosan hybrid nanoparticles with a significant difference from the bare hybrid nanoparticles in some of the inflammatory markers. The anti-inflammatory effect of the gold conjugate was also evident by a lower spleen to body weight ratio and a better histopathological skin condition compared to other tested formulations.
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