生物加工
脚手架
3d打印
纳米技术
3D打印
计算机科学
组织工程
寄主(生物学)
生物医学工程
材料科学
工程类
生物
机械工程
生态学
数据库
作者
Akshat Joshi,Sagnik Ray Choudhury,Sriram Bharath Gugulothu,Sandhya S. Visweswariah,Kaushik Chatterjee
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2022-06-13
卷期号:23 (7): 2730-2751
被引量:20
标识
DOI:10.1021/acs.biomac.2c00423
摘要
Three-dimensional (3D) printing techniques for scaffold fabrication have shown promising advancements in recent years owing to the ability of the latest high-performance printers to mimic the native tissue down to submicron scales. Nevertheless, host integration and performance of scaffolds in vivo have been severely limited owing to the lack of robust strategies to promote vascularization in 3D printed scaffolds. As a result, researchers over the past decade have been exploring strategies that can promote vascularization in 3D printed scaffolds toward enhancing scaffold functionality and ensuring host integration. Various emerging strategies to enhance vascularization in 3D printed scaffolds are discussed. These approaches include simple strategies such as the enhancement of vascular in-growth from the host upon implantation by scaffold modifications to complex approaches wherein scaffolds are fabricated with their own vasculature that can be directly anastomosed or microsurgically connected to the host vasculature, thereby ensuring optimal integration. The key differences among the techniques, their pros and cons, and the future opportunities for utilizing each technique are highlighted here. The Review concludes with the current limitations and future directions that can help 3D printing emerge as an effective biofabrication technique to realize tissues with physiologically relevant vasculatures to ultimately accelerate clinical translation.
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