山梨酸钾
遗传毒性
山梨酸
微核
氧化应激
防腐剂
微核试验
超氧化物歧化酶
化学
钾
食品科学
毒性
毒理
生物化学
生物
有机化学
糖
作者
Malinee Pongsavee,Rajnikant Mishra
出处
期刊:Indian journal of forensic medicine and toxicology
[Institute of Medico-legal Publications Private Limited]
日期:2021-03-24
卷期号:15 (2): 2795-2803
被引量:5
标识
DOI:10.37506/ijfmt.v15i2.14795
摘要
Potassium sorbate, a potassium salt of sorbic acid, has been used as food preservative and antimicrobial agent.Some observations in rat and hamster cells suggest its toxicity. However, observations in human cells arelimiting. Therefore, it has been intended to investigate impacts of potassium sorbate on human lymphocytes.The lymphocytes were cultured and treated with 0.5, 1.0, 1.5 and 2.0 mg/ml of potassium sorbate for 24 and48 h. Evaluations of its impacts were done through the MTT assay, analysis of chromosomal aberrations,formation of micronucleus and activities of superoxide dismutase. The results revealed that potassiumsorbate induced oxidative stress, genotoxicity, damages to chromosome, formation of micronucleus inhuman lymphocytes.
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