P223 Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patient with intestinal Behçet’s disease as a marker of disease activity and prognosis

Abstract Background The neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are used as a diagnostic marker, disease activity marker, and prognostic marker in patients with Crohn’s disease and ulcerative colitis. We aimed to investigate the NLR and PLR as a marker of inflammation and prognostic biomarker in intestinal Behçet’s disease (BD). Methods A total of 1712 diagnostic tests with 621 intestinal BD patients who underwent both blood examination and endoscopic examination at the Inflammatory Bowel Disease Clinic of Severance Hospital, Seoul, Korea between March 2005 to November 2020 were analyzed in our study. We analyzed to identify the independent risk factors of the clinical remission (CR) and endoscopic remission (ER). Moreover, for 435 patients who underwent a series of blood and endoscopic examination, we performed Kaplan-Meier (K-M) analyses to identify the NLR and PLR as a marker of prognosis in intestinal BD. Results The NLR levels were higher in non-CR group compared to CR group (3.3±2.7 vs. 2.0±1.2, p<0.001). The PLR levels were higher in non-CR group compared to CR group (192.9±113.8 vs. 139.6±63.757, p<0.001). The NLR levels were higher in non-ER group compared to ER group (2.8±2.2 vs. 2.0±1.3, p<0.001). The PLR levels were higher in non-ER group compared to CR group (171.5±171.5 vs. 136.3±54.4, p<0.001). In the CR group and the ER group, NLR and PLR were meaningful indicators for predicting each remission. We obtained the cut-off values of NLR(CR group 3.17, ER group 2.53) and PLR(CR group 187.28, ER group 124.27). There was a significant difference in the duration of CR/ER remission when the NLR/PLR high group and low NLR/PLR group were applied with the K-M curve based on cut-off. Conclusion The NLR and PLR were higher in patients with active intestinal BD compared to those with inactive intestinal BD. And the NLR and PLR showed a promising role as marker for prediction of disease prognosis. Therefore, the NLR and PLR might be effective, readily available, and low-cost biomarkers for inflammation in intestinal BD patients.