纳米颗粒
生物结合
超顺磁性
生物分子
胶体
氧化铁纳米粒子
磁性纳米粒子
纳米技术
热稳定性
材料科学
化学
磁热疗
磁共振成像
核磁共振
磁化
磁场
有机化学
放射科
量子力学
医学
物理
作者
K.C. Barick,Sarika Singh,D. Bahadur,Malini Lawande,Deepak Patkar,P. A. Hassan
标识
DOI:10.1016/j.jcis.2013.11.076
摘要
We report the development of carboxyl decorated iron oxide nanoparticles (CIONs) by a facile soft-chemical approach for magnetic resonance imaging (MRI) and hyperthermia applications. These superparamagnetic CIONs (~10 nm) are resistant to protein adsorption under physiological medium and exhibit good colloidal stability, magnetization and cytocompatibility with cell lines. Analysis of the T2-weighted MRI scans of CIONs in water yields a transverse relaxivity (r2) value of 215 mM(-1) s(-1). The good colloidal stability and high r2 value make these CIONs as promising candidates for high-efficiency T2 contrast agent in MRI. Further, these biocompatible nanoparticles show excellent self-heating efficacy under external AC magnetic field (AMF). The infrared thermal imaging confirmed the localized heating of CIONs under AMF. Thus, these carboxyl decorated Fe3O4 nanoparticles can be used as a contrast agent in MRI as well as localized heat activated killing of cancer cells. Furthermore, the active functional groups (COOH) present on the surface of Fe3O4 nanoparticles can be accessible for routine conjugation of biomolecules/drugs through well-developed bioconjugation chemistry.
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