Pigmented epithelioid melanocytoma

病理 医学 解剖 结核(地质) 蓝痣 真皮 网状真皮 病变 核异型性 真皮乳头状 异型性 黑色素瘤 生物 免疫组织化学 癌症研究 古生物学
作者
Jon R. Ward,Stephen Brady,Hiroomi Tada,Nikki Levin
出处
期刊:International Journal of Dermatology [Wiley]
卷期号:45 (12): 1403-1405 被引量:202
标识
DOI:10.1111/j.1365-4632.2006.02883.x
摘要

A 16-year-old Hispanic male presented with a nontender purple nodule on the right shoulder that had been present for 1 year. There was no personal or family history of skin cancer. He had no significant past medical history. Physical examination revealed a 10 mm × 5 mm, firm, dark purple nodule on the right anterior shoulder (Fig. 1). The surface was not eroded or crusted. The nodule was not attached to underlying structures. A deep shave excision was performed. Figure 1Open in figure viewerPowerPoint Clinical photograph of tumor of the right anterior shoulder Microscopic examination showed a polypoid tumor composed of heavily pigmented epithelioid melanocytes and melanophages with collagenous stroma (2, 3). Clusters of tumor cells were seen within the papillary dermis to lie in close apposition to the epidermis, which was variably hyperplastic and attenuated, but the lesion was predominantly dermal with only occasional atypical melanocytes disposed singly along the basal layer. The lesion appeared well circumscribed and, although quite thick at 3.42 mm, extended only superficially into the reticular dermis, the thickness being largely the result of protuberant growth. The nuclear detail was obscured by the copious melanin, and a bleached preparation was also examined. These sections revealed only mild cellular atypia, with round nuclear contours, open chromatin with peripheral margination, and a single distinct but small nucleolus; cytoplasm was abundant and no mitotic figures were identified. Ulceration, significant host lymphocyte response, lymphovascular invasion, and microsatellitosis were also absent. The diagnosis of animal (equine)-type melanoma was favored over other pigmented nevomelanocytic lesions, including cellular blue nevus, blue nevus with hypercellularity, and regressive tumoral melanosis. Figure 2Open in figure viewerPowerPoint Low-power histopathology of biopsy specimen (hematoxylin and eosin, ×10) Figure 3Open in figure viewerPowerPoint High-power histopathology of biopsy specimen (hematoxylin and eosin, ×100) Complete physical examination performed at the next follow-up visit revealed no lymphadenopathy or organomegaly. Serum lactate dehydrogenase and chest radiographs were normal. The patient underwent lymphoscintigraphy (Fig. 4) followed by wide local excision (2 cm margins), intraoperative lymphatic mapping, and sentinel lymph node biopsy (Fig. 5) 3 weeks after the initial biopsy. Three sentinel lymph nodes were identified in the right axilla and excised. All were grossly negative for tumor. Microscopic examination, however, showed two of the nodes to harbor subcapsular and intraparenchymal tumor deposits (Fig. 6), which were immunoreactive for S-100 protein and Mart-1. Computed tomography scans of the chest, abdomen, and pelvis did not demonstrate metastatic disease. Complete axillary lymph node dissection was recommended, but the patient and his family declined. At 6 months after the patient's initial diagnosis, he was free of any overt metastatic disease. Figure 4Open in figure viewerPowerPoint Lymphoscintigraphy Figure 5Open in figure viewerPowerPoint Sentinel lymph node (in vivo) Figure 6Open in figure viewerPowerPoint Sentinel lymph node (hematoxylin and eosin, ×25)
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