肌成纤维细胞
成纤维细胞
心脏纤维化
心脏电生理学
纤维化
电生理学
心肌细胞
心肌细胞
细胞外基质
细胞生理学
医学
心肌纤维化
细胞生物学
生物
内科学
神经科学
体外
细胞
遗传学
作者
Carolina Vásquez,Najate Benamer,Gregory E. Morley
出处
期刊:Journal of Cardiovascular Pharmacology
[Ovid Technologies (Wolters Kluwer)]
日期:2011-04-01
卷期号:57 (4): 380-388
被引量:126
标识
DOI:10.1097/fjc.0b013e31820cda19
摘要
Cardiac fibrosis occurs in a number of cardiovascular diseases associated with a high incidence of arrhythmias. A critical event in the development of fibrosis is the transformation of fibroblasts into an active phenotype or myofibroblast. This transformation results in functional changes including increased proliferation and changes in the release of signaling molecules and extracellular matrix deposition. Traditionally, fibroblasts have been considered to affect cardiac electrophysiology indirectly by physically isolating myocytes and creating conduction barriers. There is now increasing evidence that cardiac fibroblasts may play a direct role in modulating the electrophysiological substrate in diseased hearts. The purpose of this review is to summarize the functional changes associated with fibroblast activation, the membrane currents that have been identified in adult cardiac fibroblasts, and describe recent studies of fibroblast-myocyte electrical interactions with emphasis on the changes that occur with cardiac injury. Further analysis of fibroblast membrane electrophysiology and their interactions with myocytes will lead to a more complete understanding of the arrhythmic substrate. These studies have the potential to generate new therapeutic approaches for the prevention of arrhythmias associated with cardiac fibrosis.
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