Ten-Year Follow-Up of a Randomized Trial of Pravastatin in Heart Transplant Patients

普伐他汀 医学 随机对照试验 心脏移植 内科学 心脏病学 移植 胆固醇
作者
Jon A. Kobashigawa,J. Moriguchi,Hillel Laks,Liane Wener,A. Hage,Michèle A. Hamilton,Gregory Cogert,A. Márquez,Maria Espejo Vassilakis,Jignesh Patel,Lawrence A. Yeatman
出处
期刊:Journal of Heart and Lung Transplantation [Elsevier BV]
卷期号:24 (11): 1736-1740 被引量:171
标识
DOI:10.1016/j.healun.2005.02.009
摘要

Background

Outcomes from this trial's first year data demonstrated significant benefit in heart transplant patients treated with pravastatin in cholesterol levels, survival, rejection with hemodynamic compromise, the development of cardiac allograft vasculopathy, and decreased natural killer cell cytotoxicity. Other heart transplant studies have shown similar benefit. We now report the 10-year follow-up of this study.

Methods

Ninety-seven heart transplant recipients were randomized to pravastatin (n = 47) or no pravastatin (n = 50) within 2 weeks after surgery both in combination with cyclosporine and corticosteroids. Ten-year outcomes include survival, cholesterol levels, and development of cardiac allograft vasculopathy documented by coronary angiography.

Results

Forty-two percent of the control patients crossed over to pravastatin treatment during the second year of the study, and 81% of the control patients were eventually placed on statin therapy by the 10-year follow-up. The control group had subsequent low and comparable cholesterol levels in Years 2 to10 of the study compared with the patients originally randomized to pravastatin. Intent-to-treat analysis demonstrated that the pravastatin group compared with control had increased 10-year survival (68% vs 48%, p = 0.026). The 10-year freedom from angiographic cardiac allograft vasculopathy and/or death in the pravastatin group was significantly greater compared with the control group (43% vs 20%, p = 0.009).

Conclusion

The 10-year follow-up of this study suggests that the use of pravastatin in heart transplant patients maintains survival benefit and appears to reduce the development of cardiac allograft vasculopathy.
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