A 1:2 cocrystal of genistein with isonicotinamide: crystal structure and Hirshfeld surface analysis

Genistein, a naturally occurring polyphenolic compound, was combined with isonicotinamide, a pharmaceutically acceptable coformer, to yield a 1:2 cocrystal [systematic name: 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one–pyridine-4-carboxamide (1/2)], C 15 H 10 O 5 ·2C 6 H 6 N 2 O. The molecules in the cocrystalline phase are present in their neutral forms, and assemble a molecular layer by means of hydrogen bonding.