自体荧光
体内
胰腺癌
病理
临床前影像学
癌症
拉曼光谱
荧光
化学
医学
生物
内科学
光学
物理
生物技术
作者
Toshiaki Suzuki,Yusuke Hattori,Takashi Katagiri,Hiroki Mitsuoka,Kenichi Sato,Toru Asakura,Tooru Shimosegawa,Hidetoshi Sato
摘要
Living pancreatic cancer tissues grown subcutaneously in nude mice are studied by in vivo Raman spectroscopy and autofluorescence imaging. Comparing the same point spectra of alive pancreatic cancer tissue to that of the dead tissue, it is found that they are different each other. The results suggest that the spectral changes reflect the protein conformational changes in the tumor tissue with death of the host animal. From the result of autofluorescence study, in vivo autofluorescence imaging has potential as a method to assign the histological elements of the pancreatic cancer tissue without any staining. These results strongly suggest that combination of these techniques is very important to study biological tissue.
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