Synthesis, Characterization, and Antibacterial Activity of Cobalt(II) and Zinc(II) Complexes with Schiff Bases

Abstract Coordination compounds of cobalt(II) and zinc(II) with Schiff bases 4-chloro-2-[(2-ethylaminoethylimino)methyl]phenol and 4-chloro-2-[(2-piperazin-1-ylethylimino)methyl]phenol, respectively, were synthesized. The characterization of the newly formed compounds was done by elemental analysis, IR spectra, molar electric conductibility, and single crystal X-ray determination. The Co atom in the cobalt complex is in an octahedral coordination, and the Zn atom in the zinc complex is in a tetrahedral coordination. The Schiff bases and the two complexes have been evaluated for their antibacterial activity against four gram-positive bacteria, Stereptococcus pyogenes, Stereptococcus agalactiae, Staphylococcus aureus, and Bacillus anthracis, and two gram-negative bacteria, Klebsiella pneumonia and Pseudomonas aeruginosa. Keywords: antibacterial activitycobalt complexcrystal structureSchiff basezinc complex Acknowledgments The financial assistance from The First Affiliated Hospital of Dalian Medical University is gratefully acknowledged.