Preparation and Properties of Drug-Loaded Chitosan-Sodium Alginate Complex Membrane

Chitosan, sodium alginate and berberine complex membranes were prepared. The structure and properties of the drug-loaded membrane were studied using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and thermal gravimetric and differential thermal analysis (DTA). The drug-release property of membranes with different ratios of chitosan and sodium alginate was also investigated. The results show that when chitosan and sodium alginate were mixed in weight ratio of 5:1, a polyelectrolyte complex film was formed and exhibited better thermal stability and stronger control ability over drug release.