败血症
免疫系统
炎症
免疫学
细胞凋亡
程序性细胞死亡
细胞因子
半胱氨酸蛋白酶
效应器
医学
生物
生物化学
作者
Richard S. Hotchkiss,Donald W. Nicholson
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2006-10-13
卷期号:6 (11): 813-822
被引量:758
摘要
An emerging concept is that sepsis is in fact due to an impaired immune response owing to excessive apoptosis of immune cells and the immunosuppressive effect that occurs as a result of the uptake of these cells. Might the use of caspase inhibitors be of therapeutic benefit in the treatment of sepsis?
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