CD40
生发中心
细胞生物学
生物
幼稚B细胞
等离子体电池
B细胞
体外
分子生物学
化学
抗体
免疫学
细胞毒性T细胞
生物化学
作者
Christophe Arpin,Julie Déchanet,Cees van Kooten,Pierre Merville,Géraldine Grouard,Francine Brière,Jacques Banchereau,Yongjun Liu
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1995-05-05
卷期号:268 (5211): 720-722
被引量:552
标识
DOI:10.1126/science.7537388
摘要
After germinal center B cells undergo somatic mutation and antigen selection, they become either memory B cells or plasma cells, but the signal requirements that control entry into either pathway have been unclear. When purified human germinal center cells were cultured with interleukin-2, interleukin-10, and cells expressing CD40 ligand, cells with characteristics of memory B cells were generated. Removal of CD40 ligand from the system resulted in terminal differentiation of germinal center B cells into cells with the characteristics of plasma cells. These results indicate that CD40 ligand directs the differentiation of germinal center B cells toward memory B cells rather than toward plasma cells.
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