基因组印记
印记(心理学)
生物
等位基因
表观遗传学
基因
遗传学
表型
基因表达
基因表达调控
DNA甲基化
作者
Christopher Gregg,Jiangwen Zhang,Brandon Weissbourd,Shujun Luo,Gary P. Schroth,David Haig,Catherine Dulac
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2010-08-06
卷期号:329 (5992): 643-648
被引量:541
标识
DOI:10.1126/science.1190830
摘要
Parental Influences Genomic imprinting results in the preferential expression of either the paternally or the maternally inherited allele of certain genes. Two papers by Gregg et al. (p. 643 , published online 8 July; and p. 682 , published online 8 July; see the Perspective by Wilkinson ) use a genome-wide approach to characterize the repertoire of genes with parent-of-origin allelic effects in the mouse embryonic and adult brain. The studies uncovered over 1300 loci with maternal or paternal allelic bias. Comparison of the parent-of-origin allelic expression bias in the adult hypothalamus and cortex, and in the developing brain, revealed spatiotemporal, sex-specific, and isoform-specific regulation. Parent-of-origin effects thus represent a major and dynamic mode of epigenetic regulation of gene expression in the brain.
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