细胞因子
信号转导
Wnt信号通路
体内
炎症
T细胞
细胞生物学
药理学
生物
免疫系统
医学
免疫学
遗传学
作者
Uwe Lendeckel,Marco Arndt,Alicja Bukowska,Janine Tadje,Carmen Wolke,Thilo Kähne,Klaus Neubert,Jürgen Faust,Annelore Ittenson,Siegfried Ansorge,Dirk Reinhold
出处
期刊:Kluwer Academic Publishers eBooks
[Kluwer Academic Publishers]
日期:2005-12-29
卷期号:: 123-131
被引量:19
标识
DOI:10.1007/0-306-47920-6_16
摘要
Inhibitors of the enzymatic activity of alanyl-aminopeptidases severely affect growth and typical functions of human peripheral T cells both in vitro and in vivo. The most prominent changes observed include the activation of cellular signal transduction pathways such as MAP kinases Erk1/2 or the Wnt-pathway, a decrease of production and release of "pro-inflammatory" cytokines (IL-2, IL-12) and, most importantly, an induction of expression and release of the immunosuppressive cytokine, TGF-beta1. Similar effects on T cell proliferation and function have been observed in response to inhibition of DPIV, which is strongly suggestive of a functional synergism of APN and DPIV. In support of this hypothesis evidence is provided showing that the simultaneous application of inhibitors of DPIV and APN further enhances the anti-inflammatory and immunosuppressive effects provoked by the inhibition of APN or DPIV alone. Therefore, the simultaneous inhibition of these enzymes represents a promising strategy for the pharmacological therapy of T cell mediated diseases such as autoimmune disease, inflammation, allergy, and allograft rejection.
科研通智能强力驱动
Strongly Powered by AbleSci AI