化学
生物催化
苯胺
加合物
绿色化学
有机化学
产量(工程)
反应机理
药物化学
催化作用
材料科学
冶金
作者
G. M. Badger,HP Crocker,BC Ennis,JA Gayler,WE Matthews,Wgc Raper,EL Samuel,TM Spotswood
摘要
Aniline and substituted anilines have been found to react, in acid solution, with αβ-unsaturated carbonyl compounds (or with substances which can be converted into αβ-unsaturated carbonyl compounds by acid) to give β-arylaminoaldehydes or ketones (IV, VIII, X), or in some cases the anil of a β-arylaminoaldehyde. These adducts have been cyclized, sometimes in good yield, to the corresponding quinolines: and the evidence indicates that compounds of these types must be intermediates m the Skraup, the Doebner-Miller, and related reactions. The mechanisms of these reactions are critically discussed. Satisfactory methods for the preparation of many quinolines have been devised, and syntheses of several new quinolines are reported.
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