化学
简单(哲学)
催化作用
保护组
群(周期表)
偶联反应
联轴节(管道)
组合化学
有机化学
计算化学
机械工程
认识论
工程类
哲学
烷基
作者
Hideki Ihara,Masashi Koyanagi,Michinori Suginome
出处
期刊:Organic Letters
[American Chemical Society]
日期:2011-04-21
卷期号:13 (10): 2662-2665
被引量:85
摘要
Anthranilamide (AAM) serves as a bifunctional modifier on the boron atom in catalytic transformations of arylboronic acids. It makes boronyl groups unreactive in Suzuki-Miyaura coupling and promotes Ru-catalyzed ortho-silylation. Suzuki-Miyaura coupling of AAM-modified bromophenylboronic acids with tolylboronic acid gave 1,1'-biaryl-4-boronic acid bearing AAM on the boron atom, which subsequently underwent Ru-catalyzed ortho-silylation at the 3-position by virtue of the ortho-directing effect of the AAM group.
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