生物
节的
节点信号
干细胞
细胞生物学
器官发生
激活素2型受体
信号
癌变
激活素受体
细胞命运测定
细胞分化
转化生长因子β信号通路
生物信息学
信号转导
癌症
解剖
转化生长因子
遗传学
转录因子
胚胎发生
胚胎
基因
原肠化
作者
Siim Pauklin,Ludovic Vallier
出处
期刊:Development
[The Company of Biologists]
日期:2015-02-15
卷期号:142 (4): 607-619
被引量:155
摘要
Activin/Nodal growth factors control a broad range of biological processes, including early cell fate decisions, organogenesis and adult tissue homeostasis. Here, we provide an overview of the mechanisms by which the Activin/Nodal signalling pathway governs stem cell function in these different stages of development. We describe recent findings that associate Activin/Nodal signalling to pathological conditions, focusing on cancer stem cells in tumorigenesis and its potential as a target for therapies. Moreover, we will discuss future directions and questions that currently remain unanswered on the role of Activin/Nodal signalling in stem cell self-renewal, differentiation and proliferation.
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