肺炎支原体
血清学
抗体
效价
医学
补体结合试验
免疫学
免疫球蛋白M
抗生素
支原体
红霉素
肺炎
内科学
免疫球蛋白G
微生物学
生物
作者
Tomas Vikerfors,Glenn Brodin,M Grandien,Lotta Hirschberg,Aud Krook,C A Pettersson
标识
DOI:10.3109/00365548809035660
摘要
The diagnostic value of detection of specific IgM antibodies was analysed in Mycoplasma pneumoniae infections. In a retrospective clinical and serological study, M. pneumoniae IgM antibodies were determined by a u-capture ELISA using enzyme-labelled antigen. The study group consisted of 91 patients with significantly raised titers in paired sera or a single high titer of complement fixation antibodies. About 40% of the patients had been treated with antibiotics ineffective against M. pneumoniae infections prior to admission to hospital. Treatment with erythromycin or tetracycline was shown to give a shorter period of fever compared to if no or ineffective therapy was given. Specific IgM antibodies were detected in about 80% of sera sampled 9 days or more after onset of symptoms. In sera sampled at 7–8 days after onset IgM antibodies were found in about 40% of the sera but only occasionally in sera sampled earlier. In the age group 0–20 years 88% of the patients developed an IgM response. In the higher ages (>60 years) a significantly lower rate of IgM responders was observed.
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