Rapid synthesis of 2,5‐disubtituted 1,3,4‐thiadiazoles under microwave irradiation

Abstract The one pot, three‐components condensation of aromatic aldehydes, hydrazine and sulfur in ethanol under microwave irradiation provided symmetrically 3,5‐disubstituted 1,3,4‐thiadiazoles in high yields and good purity. This reaction must be conducted under pressure of hydrogen sulfide produced in‐situ . The structure of the compounds was confirmed by 1 H, 13 C NMR, MS and elemental analysis.