Association of Gestational Diabetes With Maternal Disorders of Glucose Metabolism and Childhood Adiposity

医学 妊娠期糖尿病 糖尿病前期 怀孕 超重 糖尿病 2型糖尿病 内科学 肥胖 体质指数 内分泌学 儿童肥胖 产科 出生体重 妊娠期 生物 遗传学
作者
William L. Lowe,Denise Scholtens,Lynn P. Lowe,Alan Kuang,Michael Nodzenski,Octavious Talbot,Patrick M. Catalano,Barbara Linder,Wendy J. Brickman,Peter Clayton,Chaicharn Deerochanawong,Jill Hamilton,Jami L. Josefson,Michele Lashley,Jean M. Lawrence,Yael Lebenthal,Ronald C.W.,Michael Maresh,David R. McCance,Wing Hung Tam,David A. Sacks,Alan Dyer,Boyd E. Metzger
出处
期刊:JAMA [American Medical Association]
卷期号:320 (10): 1005-1005 被引量:389
标识
DOI:10.1001/jama.2018.11628
摘要

The sequelae of gestational diabetes (GD) by contemporary criteria that diagnose approximately twice as many women as previously used criteria are unclear.To examine associations of GD with maternal glucose metabolism and childhood adiposity 10 to 14 years' postpartum.The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study established associations of glucose levels during pregnancy with perinatal outcomes and the follow-up study evaluated the long-term outcomes (4697 mothers and 4832 children; study visits occurred between February 13, 2013, and December 13, 2016).Gestational diabetes was defined post hoc using criteria from the International Association of Diabetes and Pregnancy Study Groups consisting of 1 or more of the following 75-g oral glucose tolerance test results (fasting plasma glucose ≥92 mg/dL; 1-hour plasma glucose level ≥180 mg/dL; 2-hour plasma glucose level ≥153 mg/dL).Primary maternal outcome: a disorder of glucose metabolism (composite of type 2 diabetes or prediabetes). Primary outcome for children: being overweight or obese; secondary outcomes: obesity, body fat percentage, waist circumference, and sum of skinfolds (>85th percentile for latter 3 outcomes).The analytic cohort included 4697 mothers (mean [SD] age, 41.7 [5.7] years) and 4832 children (mean [SD] age, 11.4 [1.2] years; 51.0% male). The median duration of follow-up was 11.4 years. The criteria for GD were met by 14.3% (672/4697) of mothers overall and by 14.1% (683/4832) of mothers of participating children. Among mothers with GD, 52.2% (346/663) developed a disorder of glucose metabolism vs 20.1% (791/3946) of mothers without GD (odds ratio [OR], 3.44 [95% CI, 2.85 to 4.14]; risk difference [RD], 25.7% [95% CI, 21.7% to 29.7%]). Among children of mothers with GD, 39.5% (269/681) were overweight or obese and 19.1% (130/681) were obese vs 28.6% (1172/4094) and 9.9% (405/4094), respectively, for children of mothers without GD. Adjusted for maternal body mass index during pregnancy, the OR was 1.21 (95% CI, 1.00 to 1.46) for children who were overweight or obese and the RD was 3.7% (95% CI, -0.16% to 7.5%); the OR was 1.58 (95% CI, 1.24 to 2.01) for children who were obese and the RD was 5.0% (95% CI, 2.0% to 8.0%); the OR was 1.35 (95% CI, 1.08 to 1.68) for body fat percentage and the RD was 4.2% (95% CI, 0.9% to 7.4%); the OR was 1.34 (95% CI, 1.08 to 1.67) for waist circumference and the RD was 4.1% (95% CI, 0.8% to 7.3%); and the OR was 1.57 (95% CI, 1.27 to 1.95) for sum of skinfolds and the RD was 6.5% (95% CI, 3.1% to 9.9%).Among women with GD identified by contemporary criteria compared with those without it, GD was significantly associated with a higher maternal risk for a disorder of glucose metabolism during long-term follow-up after pregnancy. Among children of mothers with GD vs those without it, the difference in childhood overweight or obesity defined by body mass index cutoffs was not statistically significant; however, additional measures of childhood adiposity may be relevant in interpreting the study findings.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
无花果应助morena采纳,获得10
1秒前
lqy发布了新的文献求助10
1秒前
科研鼠完成签到,获得积分10
2秒前
呆瓜完成签到,获得积分10
2秒前
肉肉完成签到,获得积分10
2秒前
开心的BILL发布了新的文献求助10
3秒前
清脆的巧凡应助ijoy采纳,获得20
3秒前
3秒前
5秒前
6秒前
脑洞疼应助土豆淀粉采纳,获得10
7秒前
震动的世开完成签到,获得积分10
8秒前
lbyscu完成签到 ,获得积分10
8秒前
呆瓜发布了新的文献求助10
8秒前
lqy完成签到,获得积分20
8秒前
活泼水桃发布了新的文献求助10
8秒前
听南发布了新的文献求助10
9秒前
孢子发布了新的文献求助10
9秒前
10秒前
张 大头完成签到,获得积分10
10秒前
11秒前
aczqay完成签到,获得积分10
11秒前
开心的BILL完成签到,获得积分10
12秒前
Joel完成签到,获得积分10
12秒前
13秒前
14秒前
15秒前
执着的日记本完成签到 ,获得积分10
15秒前
善学以致用应助han采纳,获得10
15秒前
15秒前
16秒前
ltt发布了新的文献求助10
16秒前
Joel发布了新的文献求助30
18秒前
小琦无敌发布了新的文献求助10
18秒前
18秒前
jj完成签到,获得积分10
19秒前
小粉完成签到,获得积分20
19秒前
20秒前
星辰大海应助ltt采纳,获得10
20秒前
土豆淀粉发布了新的文献求助10
21秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Effective Learning and Mental Wellbeing 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975953
求助须知:如何正确求助?哪些是违规求助? 3520269
关于积分的说明 11201866
捐赠科研通 3256738
什么是DOI,文献DOI怎么找? 1798436
邀请新用户注册赠送积分活动 877578
科研通“疑难数据库(出版商)”最低求助积分说明 806464