吸入
药物输送
医学
糖尿病
胰岛素
药理学
肺
微球
材料科学
生物医学工程
麻醉
内科学
纳米技术
内分泌学
化学工程
工程类
作者
Xiao‐Fen Lin,Ranjith Kumar Kankala,Na Tang,Peiyao Xu,Liu‐Zhi Hao,Dayun Yang,Shi‐Bin Wang,Yu Shrike Zhang,Ai‐Zheng Chen
标识
DOI:10.1002/adhm.201800910
摘要
Abstract Pulmonary delivery of drugs has attracted increasing attention in healthcare, as the lungs are an easily accessible site for noninvasive systemic delivery of drugs. Although pulmonary inhalation of porous microparticles has been shown to sustain drug delivery, there are limited reports on efficient delivery of insulin and inhalation therapy of diabetes based on supercritical carbon dioxide (SC‐CO 2 ) technology. Herein, this study reports the fabrication of insulin‐loaded poly‐ l ‐lactide porous microspheres (INS‐PLLA PMs) by using the SC‐CO 2 technology, and their use as an inhalation delivery system potentially for diabetes therapy. Biocompatibility and delivery efficiency of the PLLA PMs in the lungs are investigated. The PLLA PMs show negligible toxicity to lung‐derived cells, resulting in no significant reduction in cell viability, as well as levels of various inflammatory mediators such as interleukin (IL)‐6, IL‐8, and tumor necrosis factor‐α, compared with the negative control group. INS‐PLLA PMs are further efficiently deposited in the trachea and the bronchi of superior lobes of the lungs, which exhibit pronounced hypoglycemic activity in induced diabetic rats. Together, the results demonstrate that the INS‐PLLA PMs have a strong potential as an effective strategy for inhalation treatment of diabetes.
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