清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Early alpha‐foetoprotein response associated with treatment efficacy of immune checkpoint inhibitors for advanced hepatocellular carcinoma

医学 肝细胞癌 内科学 危险系数 胃肠病学 置信区间 实体瘤疗效评价标准 肿瘤科 化疗 进行性疾病
作者
Yu‐Yun Shao,Tsung‐Hao Liu,Chiun Hsu,Li-Chun Lü,Yin‐Chung Shen,Zhong‐Zhe Lin,Ann‐Lii Cheng,Chih‐Hung Hsu
出处
期刊:Liver International [Wiley]
卷期号:39 (11): 2184-2189 被引量:72
标识
DOI:10.1111/liv.14210
摘要

Abstract Background Post‐treatment decline in serum alpha‐foetoprotein (AFP) levels has been shown to predict the treatment efficacy of antiangiogenic therapy for advanced hepatocellular carcinoma (HCC). We explored whether a decline in AFP levels was also associated with treatment outcomes of immune checkpoint inhibitors (ICIs) in patients with advanced HCC. Methods We reviewed all patients who received ICI therapy for advanced HCC. AFP response was evaluated in patients with the pretreatment AFP level of >20 ng/mL. We defined early AFP response as a >20% decline in serum AFP levels within the first 4 weeks of treatment initiation relative to pretreatment levels. We then studied whether early AFP response was associated with treatment outcomes. Results Sixty patients were enrolled in this study; 43 of them were evaluable for early AFP response. The objective response rate of early AFP responders was significantly higher than that of early AFP nonresponders (73% vs. 14%, P < .001). Early AFP responders, compared with early AFP nonresponders, exhibited significantly longer overall survival (OS) (median, 28.0 vs 11.2 months, P = .048) and progression‐free survival (PFS) (median, 15.2 vs 2.7 months, P = .002). After adjusting for other clinicopathological variables and treatments, early AFP response remained an independent predictor for longer OS (hazard ratio [HR] = 0.089, 95% confidence interval [CI] = 0.018‐0.441; P = .003) and PFS (HR = 0.128, 95% CI = 0.041‐0.399; P < .001). Conclusion Early AFP response was associated with higher treatment efficacy of ICIs for advanced HCC. Additional validation studies are nonetheless warranted.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
ceeray23发布了新的文献求助20
1秒前
忒寒碜完成签到,获得积分10
12秒前
橙子完成签到 ,获得积分10
13秒前
追梦发布了新的文献求助10
19秒前
英俊的铭应助笨笨的寄真采纳,获得10
27秒前
顺利毕业完成签到 ,获得积分10
29秒前
默默完成签到 ,获得积分10
34秒前
37秒前
tyro完成签到,获得积分10
46秒前
husky完成签到,获得积分10
46秒前
zzhui完成签到,获得积分10
1分钟前
徐伟康完成签到 ,获得积分10
1分钟前
Aswl完成签到 ,获得积分10
1分钟前
1分钟前
冷傲凝琴完成签到,获得积分10
1分钟前
LEE123完成签到,获得积分10
1分钟前
ceeray23发布了新的文献求助50
1分钟前
ming123ah完成签到,获得积分10
1分钟前
西瓜完成签到 ,获得积分10
1分钟前
完美世界应助科研通管家采纳,获得10
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
小小完成签到,获得积分10
1分钟前
大力的紊发布了新的文献求助50
2分钟前
2分钟前
ceeray23发布了新的文献求助20
2分钟前
CHEN完成签到 ,获得积分10
2分钟前
LJ_2完成签到 ,获得积分10
2分钟前
dingding发布了新的文献求助10
2分钟前
2分钟前
laber完成签到,获得积分0
2分钟前
zxx完成签到 ,获得积分10
2分钟前
开心完成签到 ,获得积分10
2分钟前
虞无声完成签到,获得积分10
3分钟前
3分钟前
harden9159完成签到,获得积分10
3分钟前
wbh发布了新的文献求助10
3分钟前
追梦完成签到,获得积分10
3分钟前
万能图书馆应助wbh采纳,获得10
3分钟前
如意的馒头完成签到 ,获得积分10
3分钟前
大力的紊完成签到,获得积分10
3分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990809
求助须知:如何正确求助?哪些是违规求助? 3532233
关于积分的说明 11256603
捐赠科研通 3271081
什么是DOI,文献DOI怎么找? 1805229
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809236