化学
四唑
过氧乙酸
溴化锌
过氧化氢
溴化物
有机化学
过滤(数学)
锌
色谱法
数学
统计
作者
Л. В. Мызников,U. N. Dmitrieva,Т. В. Артамонова,Jaroslav Roh,Alexandr Hrabálek,Yu. É. Zevatskii
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2013-05-15
卷期号:45 (14): 2029-2033
被引量:7
标识
DOI:10.1055/s-0033-1338935
摘要
1-Substituted 1H-tetrazole-5-thiols were efficiently converted into the corresponding 1-substituted 5-bromo-1H-tetrazoles by treatment with zinc(II) bromide and 50% hydrogen peroxide or 36% peracetic acid at 70–80 °C. In most cases, the 5-bromotetrazole products could be isolated simply by dilution of the reaction mixture with water followed by filtration and washing of the precipitated product. Column chromatography was needed only in the case of one tetrazole that was additionally brominated on its side chain under the reaction conditions.
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