New developments in solid-state fermentation

生物反应器 生化工程 放大 过程开发 工艺工程 稳健性(进化) 过程(计算) 比例(比率) 计算机科学 固态发酵 工作(物理) 发酵 环境科学 机械工程 工程类 化学 物理 有机化学 生物化学 操作系统 食品科学 基因 经典力学 量子力学
作者
David A. Mitchell,Nádia Krieger,Deidre M. Stuart,Ashok Pandey
出处
期刊:Process Biochemistry [Elsevier BV]
卷期号:35 (10): 1211-1225 被引量:216
标识
DOI:10.1016/s0032-9592(00)00157-6
摘要

Over the last decade there has been a significant improvement in understanding how to design, operate and scale-up solid-state fermentation bioreactors. The key to these advances has been the application of mathematical modeling techniques to describe the biological and transport phenomena within the system. This review focuses on the advances in understanding that have come from this modeling work, and the insights it has given us into bioreactor design, operation and scale-up. It also highlights two promising bioreactor designs that have emerged over the last decade or so. For processes in which the substrate bed must remain static throughout the fermentation, the most promising design is the Zymotis design of ORSTOM at Montpellier, France, which involves closely spaced internal heat transfer plates within a packed-bed bioreactor. For those processes in which mixing can be tolerated, the stirred bioreactor developed at INRA, in Dijon, France, has been successfully demonstrated at scales of 1–25 t of substrate. Theoretical work suggests that mathematical models will be useful tools in the scale-up process, however, there are no reports that they have been used in the development of any current large-scale process. Rather, the models have been validated against data obtained from laboratory-scale bioreactors. There is an urgent need to test the accuracy and robustness of the models by applying them within real process development.
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