Early occupational exposure to lead on neutrophil-to-lymphocyte ratio and genotoxicity

遗传毒性 淋巴细胞 职业暴露 铅(地质) 环境卫生 铅暴露 免疫学 医学 毒理 环境科学 毒性 生物 内科学 古生物学
作者
Meng Yu,Kan Wang,Tuanwei Wang,Yuting Tu,Shiyang Gong,Yunxia Zhang,Guanghui Zhang,William W. Au,David C. Christiani,Zhao‐lin Xia
出处
期刊:Environment International [Elsevier]
卷期号:151: 106448-106448 被引量:18
标识
DOI:10.1016/j.envint.2021.106448
摘要

Lead (Pb) is known to induce detrimental health effects in exposed populations, including hematotoxicity and genotoxicity. Complete blood count (CBC) is a cost-effective and easy way to determine toxicity, and variations in proportion of different types of leukocytes: neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) are further evidence of hematotoxicity. However, few studies have been conducted to systematically evaluate effects of occupational Pb exposure on NLR and LMR, and their associations with genotoxicity.Our study was aimed to systematically assess the effects of current occupational Pb exposure on NLR and LMR, and their associations with genotoxicity.Our investigation was performed on 1176 workers from a newly built battery factory in North China. The workers had just entered their current job position in recent years and most of them had no previous history of occupational exposure to Pb. Blood lead levels (BLLs) and leukocytes indices were detected for all participants. Cytokinesis-blocked micronucleus assay (MN; n = 675) and alkaline comet assay (% tail DNA; n = 869) were used to assess genotoxicity. Multivariate linear and Poisson regression analyses were conducted to examine associations between leukocytes indices, genotoxic biomarkers and BLLs with adjustment for covariates. Spearman correlation and mediation analyses were used to investigate relationships between NLR and genotoxicity.Among all the exposed workers, NLR increased with increasing BLLs. However, WBC and LMR did not change significantly. Significant and dose-dependent increases in both MN frequencies and % tail DNA were observed among groups with different exposure doses. Compared with the normal NLR group (1.48 ≤ NLR < 4.58), the high NLR group (NLR ≥ 4.58) had higher % tail DNA. In addition, there was a significant and positive association between NLR and % tail DNA among all the workers, and % tail DNA mediated 15% of the effect of Pb on increasing NLR.Our large-scale population study shows that Pb exposure increased NLR and induced genotoxicity. There was an association between elevated NLR and DNA damage. In addition, the mediation effect of % tail DNA on the relationship between BLLs and NLR provided mechanistic evidence that certain mechanisms, e.g. inflammation, may be involved in elevation of NLR from Pb exposure. Therefore, NLR may be a convenient and sensitive biomarker for indication of Pb toxicity. Further studies are needed to validate the proposed mechanism and NLR as a biomarker.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
wuta完成签到,获得积分10
2秒前
快乐咸鱼完成签到 ,获得积分10
6秒前
6秒前
果酱君完成签到,获得积分10
10秒前
hhhzzy完成签到 ,获得积分10
11秒前
manforfull完成签到,获得积分10
11秒前
11秒前
天亮了吗发布了新的文献求助20
12秒前
材化小将军完成签到,获得积分10
14秒前
Oxygen发布了新的文献求助10
14秒前
yuki完成签到 ,获得积分10
15秒前
zhutier发布了新的文献求助10
15秒前
李爱国应助温暖的寄云采纳,获得10
15秒前
去去去去完成签到,获得积分10
17秒前
小丫发布了新的文献求助10
17秒前
天天快乐应助豆豆采纳,获得10
19秒前
21秒前
21秒前
24秒前
zzzsnsjs完成签到,获得积分10
25秒前
26秒前
安紊完成签到,获得积分10
26秒前
26秒前
FashionBoy应助独木舟采纳,获得10
27秒前
xiaofeidiao完成签到,获得积分10
28秒前
苍禾发布了新的文献求助10
29秒前
31秒前
遇见完成签到,获得积分10
32秒前
我是老大应助小小林柒染采纳,获得10
33秒前
勤奋的灯完成签到 ,获得积分10
34秒前
CodeCraft应助xixi采纳,获得10
36秒前
独木舟完成签到,获得积分10
36秒前
manfullmoon完成签到,获得积分10
37秒前
执着的笑南完成签到,获得积分20
38秒前
zhangqq完成签到,获得积分10
39秒前
天亮了吗完成签到,获得积分10
39秒前
英姑应助xu采纳,获得10
40秒前
42秒前
芝诺的乌龟完成签到 ,获得积分0
43秒前
43秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2024 Medicinal Chemistry Reviews 400
Dictionary of socialism 350
Mixed-anion Compounds 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3197862
求助须知:如何正确求助?哪些是违规求助? 2846631
关于积分的说明 8060019
捐赠科研通 2511518
什么是DOI,文献DOI怎么找? 1343436
科研通“疑难数据库(出版商)”最低求助积分说明 639537
邀请新用户注册赠送积分活动 609146