清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Early occupational exposure to lead on neutrophil-to-lymphocyte ratio and genotoxicity

遗传毒性 淋巴细胞 职业暴露 铅(地质) 环境卫生 铅暴露 免疫学 医学 毒理 环境科学 毒性 生物 内科学 古生物学
作者
Meng Yu,Kan Wang,Tuanwei Wang,Yuting Tu,Shiyang Gong,Yunxia Zhang,Guanghui Zhang,William W. Au,David C. Christiani,Zhao‐lin Xia
出处
期刊:Environment International [Elsevier]
卷期号:151: 106448-106448 被引量:18
标识
DOI:10.1016/j.envint.2021.106448
摘要

Lead (Pb) is known to induce detrimental health effects in exposed populations, including hematotoxicity and genotoxicity. Complete blood count (CBC) is a cost-effective and easy way to determine toxicity, and variations in proportion of different types of leukocytes: neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) are further evidence of hematotoxicity. However, few studies have been conducted to systematically evaluate effects of occupational Pb exposure on NLR and LMR, and their associations with genotoxicity.Our study was aimed to systematically assess the effects of current occupational Pb exposure on NLR and LMR, and their associations with genotoxicity.Our investigation was performed on 1176 workers from a newly built battery factory in North China. The workers had just entered their current job position in recent years and most of them had no previous history of occupational exposure to Pb. Blood lead levels (BLLs) and leukocytes indices were detected for all participants. Cytokinesis-blocked micronucleus assay (MN; n = 675) and alkaline comet assay (% tail DNA; n = 869) were used to assess genotoxicity. Multivariate linear and Poisson regression analyses were conducted to examine associations between leukocytes indices, genotoxic biomarkers and BLLs with adjustment for covariates. Spearman correlation and mediation analyses were used to investigate relationships between NLR and genotoxicity.Among all the exposed workers, NLR increased with increasing BLLs. However, WBC and LMR did not change significantly. Significant and dose-dependent increases in both MN frequencies and % tail DNA were observed among groups with different exposure doses. Compared with the normal NLR group (1.48 ≤ NLR < 4.58), the high NLR group (NLR ≥ 4.58) had higher % tail DNA. In addition, there was a significant and positive association between NLR and % tail DNA among all the workers, and % tail DNA mediated 15% of the effect of Pb on increasing NLR.Our large-scale population study shows that Pb exposure increased NLR and induced genotoxicity. There was an association between elevated NLR and DNA damage. In addition, the mediation effect of % tail DNA on the relationship between BLLs and NLR provided mechanistic evidence that certain mechanisms, e.g. inflammation, may be involved in elevation of NLR from Pb exposure. Therefore, NLR may be a convenient and sensitive biomarker for indication of Pb toxicity. Further studies are needed to validate the proposed mechanism and NLR as a biomarker.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
XZZ完成签到 ,获得积分10
4秒前
南宫炽滔完成签到 ,获得积分10
38秒前
现代青枫应助科研通管家采纳,获得20
56秒前
锦鲤完成签到 ,获得积分10
1分钟前
vsvsgo完成签到,获得积分10
1分钟前
zwenng完成签到,获得积分10
1分钟前
2分钟前
龙猫爱看书完成签到,获得积分10
2分钟前
简单静槐发布了新的文献求助10
2分钟前
vbnn完成签到 ,获得积分10
2分钟前
小蘑菇应助科研通管家采纳,获得10
2分钟前
lovexa完成签到,获得积分10
3分钟前
腰果虾仁完成签到 ,获得积分10
3分钟前
阿巴完成签到 ,获得积分10
4分钟前
王浩伟完成签到 ,获得积分10
4分钟前
Tong完成签到,获得积分0
5分钟前
伍仨仨完成签到,获得积分10
5分钟前
Jenny完成签到,获得积分10
6分钟前
creep2020完成签到,获得积分10
6分钟前
6分钟前
liangliu完成签到 ,获得积分10
7分钟前
冷傲的迎南完成签到 ,获得积分10
7分钟前
现代青枫应助科研通管家采纳,获得20
8分钟前
Rosie发布了新的文献求助10
9分钟前
清脆安南完成签到 ,获得积分10
10分钟前
万能图书馆应助Acuity采纳,获得10
10分钟前
11分钟前
可爱慕卉发布了新的文献求助80
11分钟前
花生油炒花生米完成签到,获得积分10
12分钟前
13分钟前
蚂蚁踢大象完成签到 ,获得积分10
13分钟前
Rosie完成签到,获得积分10
14分钟前
小事完成签到 ,获得积分10
14分钟前
咯咯咯完成签到 ,获得积分10
14分钟前
ok完成签到,获得积分10
14分钟前
zenabia完成签到 ,获得积分10
14分钟前
amar完成签到 ,获得积分0
15分钟前
123完成签到 ,获得积分10
15分钟前
拓跋雨梅完成签到 ,获得积分0
15分钟前
15分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
Handbook on People's China (1957) 400
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3190081
求助须知:如何正确求助?哪些是违规求助? 2839405
关于积分的说明 8023496
捐赠科研通 2502221
什么是DOI,文献DOI怎么找? 1336379
科研通“疑难数据库(出版商)”最低求助积分说明 637836
邀请新用户注册赠送积分活动 605974