清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Early occupational exposure to lead on neutrophil-to-lymphocyte ratio and genotoxicity

遗传毒性 淋巴细胞 职业暴露 铅(地质) 环境卫生 铅暴露 免疫学 医学 毒理 环境科学 毒性 生物 内科学 古生物学
作者
Meng Yu,Kan Wang,Tuanwei Wang,Yuting Tu,Shiyang Gong,Yunxia Zhang,Guanghui Zhang,William W. Au,David C. Christiani,Zhao‐lin Xia
出处
期刊:Environment International [Elsevier]
卷期号:151: 106448-106448 被引量:18
标识
DOI:10.1016/j.envint.2021.106448
摘要

Lead (Pb) is known to induce detrimental health effects in exposed populations, including hematotoxicity and genotoxicity. Complete blood count (CBC) is a cost-effective and easy way to determine toxicity, and variations in proportion of different types of leukocytes: neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) are further evidence of hematotoxicity. However, few studies have been conducted to systematically evaluate effects of occupational Pb exposure on NLR and LMR, and their associations with genotoxicity.Our study was aimed to systematically assess the effects of current occupational Pb exposure on NLR and LMR, and their associations with genotoxicity.Our investigation was performed on 1176 workers from a newly built battery factory in North China. The workers had just entered their current job position in recent years and most of them had no previous history of occupational exposure to Pb. Blood lead levels (BLLs) and leukocytes indices were detected for all participants. Cytokinesis-blocked micronucleus assay (MN; n = 675) and alkaline comet assay (% tail DNA; n = 869) were used to assess genotoxicity. Multivariate linear and Poisson regression analyses were conducted to examine associations between leukocytes indices, genotoxic biomarkers and BLLs with adjustment for covariates. Spearman correlation and mediation analyses were used to investigate relationships between NLR and genotoxicity.Among all the exposed workers, NLR increased with increasing BLLs. However, WBC and LMR did not change significantly. Significant and dose-dependent increases in both MN frequencies and % tail DNA were observed among groups with different exposure doses. Compared with the normal NLR group (1.48 ≤ NLR < 4.58), the high NLR group (NLR ≥ 4.58) had higher % tail DNA. In addition, there was a significant and positive association between NLR and % tail DNA among all the workers, and % tail DNA mediated 15% of the effect of Pb on increasing NLR.Our large-scale population study shows that Pb exposure increased NLR and induced genotoxicity. There was an association between elevated NLR and DNA damage. In addition, the mediation effect of % tail DNA on the relationship between BLLs and NLR provided mechanistic evidence that certain mechanisms, e.g. inflammation, may be involved in elevation of NLR from Pb exposure. Therefore, NLR may be a convenient and sensitive biomarker for indication of Pb toxicity. Further studies are needed to validate the proposed mechanism and NLR as a biomarker.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
日暮炊烟完成签到 ,获得积分0
14秒前
21秒前
美满的皮卡丘完成签到 ,获得积分10
23秒前
曾经枫发布了新的文献求助10
25秒前
naczx完成签到,获得积分0
34秒前
Akim应助曾经枫采纳,获得10
41秒前
Lancelot完成签到,获得积分0
43秒前
勤劳的颤完成签到 ,获得积分10
43秒前
harden9159完成签到,获得积分10
1分钟前
游01完成签到 ,获得积分10
1分钟前
1分钟前
维维完成签到 ,获得积分10
2分钟前
玉鱼儿完成签到 ,获得积分10
2分钟前
木南大宝完成签到 ,获得积分10
2分钟前
FANPENG发布了新的文献求助10
2分钟前
xiaoputaor完成签到 ,获得积分10
2分钟前
2分钟前
Casey完成签到 ,获得积分10
2分钟前
姚芭蕉完成签到 ,获得积分0
2分钟前
高不二发布了新的文献求助20
2分钟前
大水完成签到 ,获得积分10
2分钟前
大头完成签到 ,获得积分10
2分钟前
yuntong完成签到 ,获得积分10
2分钟前
FANPENG完成签到,获得积分10
2分钟前
luckygirl完成签到 ,获得积分10
2分钟前
研友_nV2ROn完成签到,获得积分10
3分钟前
古炮完成签到 ,获得积分10
3分钟前
张振宇完成签到 ,获得积分10
3分钟前
Skywings完成签到,获得积分10
3分钟前
雪花完成签到 ,获得积分10
3分钟前
Glory完成签到 ,获得积分10
3分钟前
张振宇完成签到 ,获得积分10
3分钟前
空洛完成签到 ,获得积分10
3分钟前
光亮若翠完成签到,获得积分10
4分钟前
卡戎529完成签到 ,获得积分10
4分钟前
Akim应助朴素蜡烛采纳,获得10
4分钟前
zz完成签到 ,获得积分10
4分钟前
caulif完成签到 ,获得积分10
4分钟前
4分钟前
qcck完成签到,获得积分10
4分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
Dictionary of socialism 350
Mixed-anion Compounds 300
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
Idoxuridine 260
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3196835
求助须知:如何正确求助?哪些是违规求助? 2845505
关于积分的说明 8054331
捐赠科研通 2510132
什么是DOI,文献DOI怎么找? 1342307
科研通“疑难数据库(出版商)”最低求助积分说明 639355
邀请新用户注册赠送积分活动 608669