Early occupational exposure to lead on neutrophil-to-lymphocyte ratio and genotoxicity

遗传毒性 淋巴细胞 职业暴露 铅(地质) 环境卫生 铅暴露 免疫学 医学 毒理 环境科学 毒性 生物 内科学 古生物学
作者
Meng Yu,Kan Wang,Tuanwei Wang,Yuting Tu,Shiyang Gong,Yunxia Zhang,Guanghui Zhang,William W. Au,David C. Christiani,Zhao‐lin Xia
出处
期刊:Environment International [Elsevier]
卷期号:151: 106448-106448 被引量:18
标识
DOI:10.1016/j.envint.2021.106448
摘要

Lead (Pb) is known to induce detrimental health effects in exposed populations, including hematotoxicity and genotoxicity. Complete blood count (CBC) is a cost-effective and easy way to determine toxicity, and variations in proportion of different types of leukocytes: neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) are further evidence of hematotoxicity. However, few studies have been conducted to systematically evaluate effects of occupational Pb exposure on NLR and LMR, and their associations with genotoxicity.Our study was aimed to systematically assess the effects of current occupational Pb exposure on NLR and LMR, and their associations with genotoxicity.Our investigation was performed on 1176 workers from a newly built battery factory in North China. The workers had just entered their current job position in recent years and most of them had no previous history of occupational exposure to Pb. Blood lead levels (BLLs) and leukocytes indices were detected for all participants. Cytokinesis-blocked micronucleus assay (MN; n = 675) and alkaline comet assay (% tail DNA; n = 869) were used to assess genotoxicity. Multivariate linear and Poisson regression analyses were conducted to examine associations between leukocytes indices, genotoxic biomarkers and BLLs with adjustment for covariates. Spearman correlation and mediation analyses were used to investigate relationships between NLR and genotoxicity.Among all the exposed workers, NLR increased with increasing BLLs. However, WBC and LMR did not change significantly. Significant and dose-dependent increases in both MN frequencies and % tail DNA were observed among groups with different exposure doses. Compared with the normal NLR group (1.48 ≤ NLR < 4.58), the high NLR group (NLR ≥ 4.58) had higher % tail DNA. In addition, there was a significant and positive association between NLR and % tail DNA among all the workers, and % tail DNA mediated 15% of the effect of Pb on increasing NLR.Our large-scale population study shows that Pb exposure increased NLR and induced genotoxicity. There was an association between elevated NLR and DNA damage. In addition, the mediation effect of % tail DNA on the relationship between BLLs and NLR provided mechanistic evidence that certain mechanisms, e.g. inflammation, may be involved in elevation of NLR from Pb exposure. Therefore, NLR may be a convenient and sensitive biomarker for indication of Pb toxicity. Further studies are needed to validate the proposed mechanism and NLR as a biomarker.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
ding应助遥远的尧采纳,获得50
4秒前
4秒前
5秒前
高兴的小完成签到,获得积分10
5秒前
中中发布了新的文献求助10
6秒前
ruiii完成签到 ,获得积分10
6秒前
000发布了新的文献求助10
6秒前
VPN不好用完成签到,获得积分10
7秒前
我是老大应助风评采纳,获得10
7秒前
云水谣完成签到,获得积分10
7秒前
8秒前
Xy发布了新的文献求助10
9秒前
张歌完成签到 ,获得积分10
9秒前
舒心的伯云完成签到 ,获得积分10
12秒前
12秒前
吴成完成签到,获得积分10
12秒前
东原角发布了新的文献求助10
13秒前
Blackmoon发布了新的文献求助10
13秒前
14秒前
14秒前
vincent完成签到,获得积分10
16秒前
17秒前
17秒前
Jasper应助一指流沙采纳,获得10
18秒前
xt完成签到,获得积分10
19秒前
充电宝应助遥远的尧采纳,获得10
21秒前
周芷卉完成签到 ,获得积分10
21秒前
幻想2993发布了新的文献求助20
21秒前
JIE发布了新的文献求助10
21秒前
22秒前
sunzhou2008完成签到,获得积分10
23秒前
云水谣发布了新的文献求助20
23秒前
斯文败类应助科研通管家采纳,获得10
23秒前
Owen应助科研通管家采纳,获得10
24秒前
rosalieshi应助科研通管家采纳,获得30
24秒前
搜集达人应助科研通管家采纳,获得10
24秒前
Ava应助科研通管家采纳,获得10
24秒前
不倦应助科研通管家采纳,获得10
24秒前
上官若男应助科研通管家采纳,获得10
24秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
Handbook on People's China (1957) 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3189139
求助须知:如何正确求助?哪些是违规求助? 2838581
关于积分的说明 8020138
捐赠科研通 2501362
什么是DOI,文献DOI怎么找? 1335573
科研通“疑难数据库(出版商)”最低求助积分说明 637620
邀请新用户注册赠送积分活动 605666