Early occupational exposure to lead on neutrophil-to-lymphocyte ratio and genotoxicity

遗传毒性 淋巴细胞 职业暴露 铅(地质) 环境卫生 铅暴露 免疫学 医学 毒理 环境科学 毒性 生物 内科学 古生物学
作者
Meng Yu,Kan Wang,Tuanwei Wang,Yuting Tu,Shiyang Gong,Yunxia Zhang,Guanghui Zhang,William W. Au,David C. Christiani,Zhao‐lin Xia
出处
期刊:Environment International [Elsevier]
卷期号:151: 106448-106448 被引量:18
标识
DOI:10.1016/j.envint.2021.106448
摘要

Lead (Pb) is known to induce detrimental health effects in exposed populations, including hematotoxicity and genotoxicity. Complete blood count (CBC) is a cost-effective and easy way to determine toxicity, and variations in proportion of different types of leukocytes: neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) are further evidence of hematotoxicity. However, few studies have been conducted to systematically evaluate effects of occupational Pb exposure on NLR and LMR, and their associations with genotoxicity.Our study was aimed to systematically assess the effects of current occupational Pb exposure on NLR and LMR, and their associations with genotoxicity.Our investigation was performed on 1176 workers from a newly built battery factory in North China. The workers had just entered their current job position in recent years and most of them had no previous history of occupational exposure to Pb. Blood lead levels (BLLs) and leukocytes indices were detected for all participants. Cytokinesis-blocked micronucleus assay (MN; n = 675) and alkaline comet assay (% tail DNA; n = 869) were used to assess genotoxicity. Multivariate linear and Poisson regression analyses were conducted to examine associations between leukocytes indices, genotoxic biomarkers and BLLs with adjustment for covariates. Spearman correlation and mediation analyses were used to investigate relationships between NLR and genotoxicity.Among all the exposed workers, NLR increased with increasing BLLs. However, WBC and LMR did not change significantly. Significant and dose-dependent increases in both MN frequencies and % tail DNA were observed among groups with different exposure doses. Compared with the normal NLR group (1.48 ≤ NLR < 4.58), the high NLR group (NLR ≥ 4.58) had higher % tail DNA. In addition, there was a significant and positive association between NLR and % tail DNA among all the workers, and % tail DNA mediated 15% of the effect of Pb on increasing NLR.Our large-scale population study shows that Pb exposure increased NLR and induced genotoxicity. There was an association between elevated NLR and DNA damage. In addition, the mediation effect of % tail DNA on the relationship between BLLs and NLR provided mechanistic evidence that certain mechanisms, e.g. inflammation, may be involved in elevation of NLR from Pb exposure. Therefore, NLR may be a convenient and sensitive biomarker for indication of Pb toxicity. Further studies are needed to validate the proposed mechanism and NLR as a biomarker.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
忘的澜完成签到,获得积分10
1秒前
ss完成签到,获得积分20
1秒前
2秒前
3秒前
吭哧吭哧完成签到,获得积分10
4秒前
英姑应助兀那狗子别跑采纳,获得10
7秒前
丘比特应助神马都不懂采纳,获得30
12秒前
蝶恋花完成签到,获得积分10
13秒前
j736999565完成签到,获得积分10
15秒前
orixero应助可乐采纳,获得10
16秒前
hhy发布了新的文献求助30
19秒前
j736999565发布了新的文献求助10
19秒前
科研通AI2S应助ABS采纳,获得10
21秒前
风趣的南霜完成签到,获得积分10
22秒前
22秒前
23秒前
JamesPei应助要减肥丸子采纳,获得10
25秒前
26秒前
沐11完成签到 ,获得积分10
26秒前
abiorz完成签到,获得积分10
27秒前
窗外是蔚蓝色完成签到,获得积分10
28秒前
水水发布了新的文献求助10
28秒前
29秒前
可乐发布了新的文献求助10
29秒前
29秒前
明天完成签到 ,获得积分10
29秒前
wyy应助Aggie采纳,获得30
30秒前
英姑应助zc北采纳,获得10
31秒前
阿Q完成签到,获得积分10
32秒前
斯文一笑发布了新的文献求助10
32秒前
Hello应助帅气的藏鸟采纳,获得10
33秒前
34秒前
搜集达人应助科研通管家采纳,获得10
34秒前
ding应助科研通管家采纳,获得10
34秒前
Leonardi应助科研通管家采纳,获得220
35秒前
ding应助科研通管家采纳,获得10
35秒前
顾白凡应助科研通管家采纳,获得30
35秒前
研友_VZG7GZ应助科研通管家采纳,获得20
35秒前
研友_VZG7GZ应助nhx采纳,获得10
35秒前
HHHAN完成签到,获得积分10
37秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
安全防范技术与工程 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
2024 Medicinal Chemistry Reviews 400
Why I Chose China [by Morris R. Wills] in "Look", February 8 and 22, 1966; 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3191440
求助须知:如何正确求助?哪些是违规求助? 2840782
关于积分的说明 8029981
捐赠科研通 2504130
什么是DOI,文献DOI怎么找? 1337447
科研通“疑难数据库(出版商)”最低求助积分说明 638080
邀请新用户注册赠送积分活动 606605