Quercetin is protective against short‐term dietary advanced glycation end products intake induced cognitive dysfunction in aged ICR mice

Journal of Food BiochemistryVolume 44, Issue 4 e13164 FULL ARTICLE Quercetin is protective against short-term dietary advanced glycation end products intake induced cognitive dysfunction in aged ICR mice Shengyi Yang, Shengyi Yang Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, ChinaSearch for more papers by this authorHuanhuan Zhou, Huanhuan Zhou Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, ChinaSearch for more papers by this authorGuiping Wang, Guiping Wang School of Physical Education, Soochow University, Suzhou, China Laboratory Animal Center, Medical College of Soochow University, Suzhou, ChinaSearch for more papers by this authorXiao-Hong Zhong, Xiao-Hong Zhong Suzhou Institute for Food Control, Suzhou, ChinaSearch for more papers by this authorQi-Liang Shen, Qi-Liang Shen Suzhou Institute for Food Control, Suzhou, ChinaSearch for more papers by this authorXue-Jing Zhang, Xue-Jing Zhang Suzhou Institute for Food Control, Suzhou, ChinaSearch for more papers by this authorRu-Yi Li, Ru-Yi Li Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, ChinaSearch for more papers by this authorLi-Hua Chen, Li-Hua Chen Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, ChinaSearch for more papers by this authorYa-Han Zhang, Corresponding Author Ya-Han Zhang smilence333@sina.com zhxwan@suda.edu.cn Suzhou Institute for Food Control, Suzhou, China Correspondence Ya-Han Zhang, Suzhou Institute for Food Control, No.1336 Wuzhong Avenue, Wuzhong District, Suzhou 215104, China. Email: smilence333@sina.com Zhongxiao Wan, Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199Ren’ai Road, Suzhou 215123, China. Email: zhxwan@suda.edu.cnSearch for more papers by this authorZhongxiao Wan, Corresponding Author Zhongxiao Wan zhxwan@suda.edu.cn orcid.org/0000-0002-6297-5933 Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, China Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Disease, Soochow University, Suzhou, China Correspondence Ya-Han Zhang, Suzhou Institute for Food Control, No.1336 Wuzhong Avenue, Wuzhong District, Suzhou 215104, China. Email: smilence333@sina.com Zhongxiao Wan, Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199Ren’ai Road, Suzhou 215123, China. Email: zhxwan@suda.edu.cnSearch for more papers by this author Shengyi Yang, Shengyi Yang Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, ChinaSearch for more papers by this authorHuanhuan Zhou, Huanhuan Zhou Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, ChinaSearch for more papers by this authorGuiping Wang, Guiping Wang School of Physical Education, Soochow University, Suzhou, China Laboratory Animal Center, Medical College of Soochow University, Suzhou, ChinaSearch for more papers by this authorXiao-Hong Zhong, Xiao-Hong Zhong Suzhou Institute for Food Control, Suzhou, ChinaSearch for more papers by this authorQi-Liang Shen, Qi-Liang Shen Suzhou Institute for Food Control, Suzhou, ChinaSearch for more papers by this authorXue-Jing Zhang, Xue-Jing Zhang Suzhou Institute for Food Control, Suzhou, ChinaSearch for more papers by this authorRu-Yi Li, Ru-Yi Li Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, ChinaSearch for more papers by this authorLi-Hua Chen, Li-Hua Chen Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, ChinaSearch for more papers by this authorYa-Han Zhang, Corresponding Author Ya-Han Zhang smilence333@sina.com zhxwan@suda.edu.cn Suzhou Institute for Food Control, Suzhou, China Correspondence Ya-Han Zhang, Suzhou Institute for Food Control, No.1336 Wuzhong Avenue, Wuzhong District, Suzhou 215104, China. Email: smilence333@sina.com Zhongxiao Wan, Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199Ren’ai Road, Suzhou 215123, China. Email: zhxwan@suda.edu.cnSearch for more papers by this authorZhongxiao Wan, Corresponding Author Zhongxiao Wan zhxwan@suda.edu.cn orcid.org/0000-0002-6297-5933 Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, China Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Disease, Soochow University, Suzhou, China Correspondence Ya-Han Zhang, Suzhou Institute for Food Control, No.1336 Wuzhong Avenue, Wuzhong District, Suzhou 215104, China. Email: smilence333@sina.com Zhongxiao Wan, Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199Ren’ai Road, Suzhou 215123, China. Email: zhxwan@suda.edu.cnSearch for more papers by this author First published: 17 February 2020 https://doi.org/10.1111/jfbc.13164Citations: 19Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Dietary advanced glycation end products (dAGEs) might be potential toxins involved in the pathogenesis of Alzheimer’s disease (AD). Quercetin is a flavonoid possessing neuroprotective effects. We aimed to explore whether a 21 days of dAGEs intake would result in cognitive dysfunction in aged ICR mice, and the protective effects of quercetin, with potential mechanisms explored. Fourteen-month old ICR mice were randomly assigned into four groups, that is, Control, AGEs, quercetin, and AGE diet supplemented with quercetin. Key markers involved in Aβ, tau, and neuroinflammation from hippocampus and cortex were measured via western blot. Gut microbiota and short chain fatty acids profiles from intestinal contents were measured via 16S rRNA gene sequencing and gas chromatography (GC), respectively. Quercetin alleviated cognitive impairment induced by dAGEs in aged mice. This might be associated with that quercetin reduced cathepsin B, tau phosphorylation, and neuroinflammation, and elevated α-diversity index (ACE, Chao1, and Shannon index), and reduced phylum Verrucomicrobia of gut microbiota. Practical applications Alzheimer’s disease (AD) has been regarded as the commonest cause of progressive dementia for the elderly. This study is the very first to demonstrate that even a short-term dietary advanced glycation end product (dAGEs) intake induced impaired cognitive function in aged ICR mice, and querectin is capable of reversing dAGEs-induced cognitive dysfunction. Reduced tau phosphorylation, neuroinflammation, and altered gut microbiota profiles may be involved in querectin’s protective effects against dAGEs-induced cognitive impairment. Our study suggested that quercetin supplementation might be beneficial for improving cognitive function in elderly subjects with high consumption of dAGEs such as grilling, frying, and broiling of food. CONFLICT OF INTERESTS The authors declare that we have no potential conflict of interest for this study. Citing Literature Volume44, Issue4April 2020e13164 RelatedInformation