先天性淋巴细胞
CD8型
免疫系统
结直肠癌
癌症研究
流式细胞术
肿瘤微环境
生物
癌症
免疫学
免疫
医学
内科学
作者
Jie Wan,Yunqiu Wu,Lan Huang,Yu Tian,Xiaoyun Ji,Mohamed Hamed Abdelaziz,Wei Cai,Kesavan Dineshkumar,Yuqing Lei,Shun Yao,Caixia Sun,Zhaoliang Su,Shengjun Wang,Huaxi Xu
标识
DOI:10.1016/j.canlet.2021.01.002
摘要
Group 2 innate lymphoid cells (ILC2s), characterized by secretion of type 2 cytokines, regulate multiple immune responses. ILC2s are found in different tumor tissues, and ILC2-derived interleukin (IL)-4, IL-5, and IL-13 act on the cells in tumor microenvironment to participate in tumor progression. ILC2s are abundant in colorectal cancer (CRC) tissue, but the role of ILC2s in CRC remains unclear. In this study, we found that the percentage of ILC2s was higher in CRC tissue than in the adjacent normal tissue and that these ILC2s were the dominant IL-9-secreting cell-subsets in CRC tissue, as shown by flow cytometry analysis. ILC2s-derived IL-9 could activate CD8+ T cells to inhibit tumor growth, while anti-IL-9 reversed this effect. In vivo experiments showed that neutralizing ILC2s promoted tumor growth, while tumor inhibition occurred by intravenous injection of IL-9. In conclusion, our results demonstrated that ILC2-derived IL-9 could activate CD8+ T cells to promote anti-tumor effects in CRC.
科研通智能强力驱动
Strongly Powered by AbleSci AI