Nanopipettes—The past and the present

纳米技术 表征(材料科学) 材料科学 生物传感器 扫描电化学显微镜 纳米尺度 扫描探针显微镜 纳米生物技术 制作 化学 纳米颗粒 电化学 电极 医学 物理化学 病理 替代医学
作者
John Stanley,Nader Pourmand
出处
期刊:APL Materials [American Institute of Physics]
卷期号:8 (10) 被引量:24
标识
DOI:10.1063/5.0020011
摘要

Nanopipettes, characterized by nanoscale sized pores and simple fabrication techniques, are of increasing scientific interest due to their application in a variety of fields, including analytical chemistry, nanophysiology, molecular diagnostics, and cellular biology. Nanopipettes have been extensively used for the development of electrochemical biosensors, as they offer the combined advantage of nanoscale dimensions and the selectivity and sensitivity of conventional solid-state biosensors. Over the years, with advances in technology and the expansion of research interests, functionalized nanopipettes have been successfully employed for performing real-time quantitative measurement of changes within a single cell. They have also been routinely used to aspirate/inject attoliter to picoliter volumes at intracellular levels and have become the “go-to” tools for cutting-edge research in molecular and cell biology. The use of nanopipettes as probes for imaging soft materials through scanning probe microscope (SPM) techniques such as scanning electrochemical microscopy and scanning ion-conductance microscopy has been widely explored. Advances in both the technical and theoretical aspects of nanopipette technology have a profound impact on early diagnosis and treatment of various diseases including cancer, diabetes, and Alzheimer’s. In this review, we provide insights into the fabrication, morphological, and electrochemical characterization of the nanopipette and comprehensively discuss the various applications available in the literature of nanopipettes as sensing probes, monitoring probes for single cells, and SPMs.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
zcbbb完成签到 ,获得积分10
2秒前
2秒前
端庄蚂蚁发布了新的文献求助10
2秒前
4秒前
焕颜完成签到,获得积分10
4秒前
NMC发布了新的文献求助10
4秒前
刘晏均完成签到,获得积分10
6秒前
大胆飞阳发布了新的文献求助10
7秒前
汉堡包应助清新的冷荷采纳,获得10
7秒前
lzx666完成签到,获得积分10
7秒前
8秒前
8秒前
粉红色的滑动变阻器完成签到 ,获得积分10
9秒前
9秒前
雅鹿贝鲁完成签到,获得积分10
10秒前
打打应助小汤采纳,获得10
11秒前
个性哑铃发布了新的文献求助20
15秒前
15秒前
16秒前
16秒前
17秒前
17秒前
17秒前
欧气满满发布了新的文献求助10
17秒前
18秒前
好运来完成签到,获得积分10
18秒前
19秒前
19秒前
思源应助bao采纳,获得10
19秒前
20秒前
caohuijun发布了新的文献求助10
21秒前
小汤发布了新的文献求助10
22秒前
23秒前
24秒前
24秒前
Haisenky发布了新的文献求助10
24秒前
zcbb完成签到,获得积分10
25秒前
whl发布了新的文献求助10
25秒前
Ice应助我要当科研大佬采纳,获得10
26秒前
27秒前
高分求助中
Sustainability in ’Tides Chemistry 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
The ACS Guide to Scholarly Communication 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Handbook of the Mammals of the World – Volume 3: Primates 805
Ethnicities: Media, Health, and Coping 800
Gerard de Lairesse : an artist between stage and studio 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3072205
求助须知:如何正确求助?哪些是违规求助? 2726027
关于积分的说明 7492250
捐赠科研通 2373536
什么是DOI,文献DOI怎么找? 1258633
科研通“疑难数据库(出版商)”最低求助积分说明 610333
版权声明 596952