共聚物
凝胶渗透色谱法
材料科学
苯硼酸
聚合物
药物输送
热重分析
热稳定性
核化学
高分子化学
毒品携带者
纳米颗粒
有机化学
化学
纳米技术
催化作用
复合材料
作者
Yunhua Zhong,Bo Song,Dan He,Zemei Xia,Peng Wang,Junzi Wu,Yan Li
出处
期刊:Nanotechnology
[IOP Publishing]
日期:2020-07-07
卷期号:31 (39): 395601-395601
被引量:18
标识
DOI:10.1088/1361-6528/ab9e26
摘要
The galactose-based polymer is a promising drug delivery material. Herein, a new galactose-based block copolymer, termed as 6-O-vinyl sebacic acid-D-galactopyranosyl ester block 3-acrylamide phenylboric acid p(OVNG-b-AAPBA) was successfully synthesized by 'block copolymer' method. The structure of p(OVNG-b-AAPBA) was proved by nuclear magnetic hydrogen spectrum (1 HNMR) and infrared (IR), the thermal stability was observed by thermogravimetric analyzer, and the molecular weights (Mw and Mn) were demonstrated by Gel permeation chromatography (GPC). The above test results suggested that the polymer of p(OVNG-b-AAPBA) was successfully synthesized, and it had optimal molecular weight and thermal stability, which could be used for investigating the drug delivery system. Then, this block copolymer was prepared to the nanoparticle (NP), these NPs had a satisfactory morphology, and their safety was verified by MTT and chronic animal toxicology test. In addition, insulin was encapsulated by the p(OVNG-b-AAPBA) NPs, the drug loading rate and encapsulation efficiency increased with that of AAPBA in the polymer. Finally, this study confirmed that these NPs can effectively maintain the blood sugar of diabetic mice at 96 h. In conclusion, the current study suggested that the insulin-loaded galactose-based polymer-block-3-acrylamide phenylboric acid NPs had slow-release/glucose-responsive drug release performance, which might play an active role in the diabetes therapy.
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