再生(生物学)
穆勒胶质细胞
重编程
视网膜再生
斑马鱼
生物
视网膜
细胞生物学
诱导多能干细胞
小RNA
干细胞
转录组
表观遗传学
电池类型
视网膜
神经科学
遗传学
基因
祖细胞
作者
Gregory Konar,Claire Ferguson,Zachary Flickinger,Matthew R. Kent,James G. Patton
标识
DOI:10.3389/fcell.2020.632632
摘要
The use of model systems that are capable of robust, spontaneous retina regeneration has allowed for the identification of genetic pathways and components that are required for retina regeneration. Complemented by mouse models in which retina regeneration can be induced after forced expression of key factors, altered chromatin accessibility, or inhibition of kinase/signaling cascades, a clearer picture of the key regulatory events that control retina regeneration is emerging. In all cases, Müller glia (MG) serve as an adult retinal stem cell that must be reprogrammed to allow for regeneration, with the end goal being to understand why regenerative pathways are blocked in mammals, but spontaneous in other vertebrates such as zebrafish. miRNAs have emerged as key gene regulatory molecules that control both development and regeneration in vertebrates. Here, we focus on a small subset of miRNAs that control MG reprogramming during retina regeneration and have the potential to serve as therapeutic targets for treatment of visual disorders and damage.
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