Progress on asparaginase-associated pancreatitis

Acute lymphoblastic leukemia(ALL)is the most common childhood malignancy.As an essential component of multiagent chemotherapy, asparaginase(ASP)has significantly improved the remission rate and event-free survival rate of children with ALL since its application in clinical practice.However, there are many adverse events due to ASP, including asparaginase-associated pancreatitis(AAP). The mechanisms behind and the risk factors predisposing AAP are unknown.This review summarizes the latest research progresses on AAP. Key words: Asparaginase; Child; Acute lymphoblastic leukemia; Pancreatitis