The research progress of hepatocellular carcinoma tumor microenvironment

The invasion, metastasis and drug resistance of hepatocellular carcinoma are the main factors affecting the prognosis of patients. Recent studies have shown that the interaction between tumor cells and the tumor microenvironment is critical for tumor cell survival, proliferation, stem cell characteristics acquisition, invasion, metastasis and drug resistance. This article discussed the progress of hepatocellular carcinoma tumor microenvironment from the contribution of hepatitis virus, liver fibrosis to microenvironment, and microenvironmental cell components and non-cellular components. Key words: Carcinoma, hepatocellular; Drug resistance, neoplasm; Tumor microenvironment