吲哚青绿
光热治疗
黑色素瘤
生物相容性材料
辐照
生物医学工程
材料科学
自愈水凝胶
化学
外科
医学
癌症研究
纳米技术
高分子化学
物理
核物理学
作者
Juyoung Hwang,Jun‐O Jin
出处
期刊:Biomolecules
[MDPI AG]
日期:2020-07-29
卷期号:10 (8): 1124-1124
被引量:24
摘要
Melanoma is the most lethal form of skin cancer because it spreads easily to other tissues, thereby decreasing the efficiency of its treatment via chemo-, radio-, and surgical therapies. We suggest the application of an attachable hydrogel for the treatment of melanoma whereby the size and amount of incorporated indocyanine green (ICG) for photothermal therapy (PTT) can be controlled. An attachable hydrogel (poly(acrylamide-co-diallyldimethylammonium chloride); PAD) that incorporates ICG as a near-infrared (NIR) absorber was fabricated using a biocompatible polymer. The temperature of PAD-ICG increases under 808 nm laser irradiation. The hydrogel protects the ICG against decomposition; consequently, PAD-ICG can be reused for PTT. The attachment of PAD-ICG to an area with melanoma in mice, with irradiation using a NIR laser, successfully eliminated melanoma. Thus, the data suggest that PAD-ICG is a smart material that could be used for selective target therapy against melanoma in humans.
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