前列腺癌
免疫组织化学
生物
前列腺
基因表达
环氧化物水解酶2
病理
信使核糖核酸
癌症
癌症研究
基因
医学
酶
遗传学
生物化学
作者
Jin Yang,Hongqing Zhou,Mingsheng Liu,Hui Zhao,Chenxiang Xu,Pingbo Xie,Wei Wang,Yang Ying-yu,Wen‐Hui Lee
标识
DOI:10.4103/aja.aja_34_20
摘要
The arachidonic acid (AA) metabolic pathway participates in various physiological processes as well as in the development of malignancies. We analyzed genomic alterations in AA metabolic enzymes in the Cancer Genome Atlas (TCGA) prostate cancer (PCa) dataset and found that the gene encoding soluble epoxide hydrolase (EPHX2) is frequently deleted in PCa. EPHX2 mRNA and protein expression in PCa was examined in multiple datasets by differential gene expression analysis and in a tissue microarray by immunohistochemistry. The expression data were analyzed in conjunction with clinicopathological variables. Both the mRNA and protein expression levels of EPHX2 were significantly decreased in tumors compared with normal prostate tissues and were inversely correlated with the Gleason grade and disease-free survival time. Furthermore, EPHX2 mRNA expression was significantly decreased in metastatic and recurrent PCa compared with localized and primary PCa, respectively. In addition, EPHX2 protein expression correlated negatively with Ki67 expression. In conclusion, EPHX2 deregulation is significantly correlated with the clinical characteristics of PCa progression and may serve as a prognostic marker for PCa.
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