清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Longitudinal molecular trajectories of diffuse glioma in adults

胶质瘤 生物 体细胞突变 癌症研究 基因 表型 癌症的体细胞进化 非整倍体 细胞周期 遗传学 染色体 抗体 B细胞
作者
Floris P Barthel,Kevin C. Johnson,Frederick S. Varn,Anzhela D. Moskalik,Georgette Tanner,Emre Kocakavuk,Kevin J. Anderson,Olajide Abiola,Kenneth Aldape,Kristin Alfaro-Munoz,Donát Alpár,Samirkumar B. Amin,David Ashley,Pratiti Bandopadhayay,Jill S. Barnholtz‐Sloan,Rameen Beroukhim,Christoph Bock,Priscilla Brastianos,Daniel J. Brat,Andrew Brodbelt,Alexander Bruns,Ketan R. Bulsara,Aruna Chakrabarty,Arnab Chakravarti,Jeffrey H. Chuang,Elizabeth B. Claus,Elizabeth J. Cochran,Jennifer Connelly,Joseph F. Costello,Gaetano Finocchiaro,Michael Fletcher,Pim J. French,Hui Gan,Mark R. Gilbert,Peter V Gould,Matthew R. Grimmer,Antonio Iavarone,Azzam Ismail,Michael D. Jenkinson,Mustafa Khasraw,Hoon Kim,Mathilde C.M. Kouwenhoven,Peter S. LaViolette,Meihong Li,Peter Lichter,Keith L. Ligon,Allison Lowman,Tathiane M Malta,Tali Mazor,Kerrie L. McDonald,Annette M. Molinaro,Do‐Hyun Nam,Naema Nayyar,Ho Keung Ng,Chew Yee Ngan,Simone P. Niclou,Johanna M. Niers,Houtan Noushmehr,Javad Noorbakhsh,D. Ryan Ormond,Chul‐Kee Park,Laila Poisson,Raúl Rabadán,Bernhard Radlwimmer,Ganesh Rao,Guido Reifenberger,K. Jason,Michael Schuster,Brian Shaw,Susan C Short,Peter A.E. Sillevis Smitt,Andrew E. Sloan,Marion Smits,Hiromichi Suzuki,Ghazaleh Tabatabai,Erwin G. Van Meir,Colin Watts,Michael Weller,Pieter Wesseling,Bart A. Westerman,Georg Widhalm,Adelheid Wöehrer,W. K. Alfred Yung,Gelareh Zadeh,Jason T. Huse,John F. de Groot,Lucy F. Stead,Roel G.W. Verhaak
出处
期刊:Nature [Nature Portfolio]
卷期号:576 (7785): 112-120 被引量:335
标识
DOI:10.1038/s41586-019-1775-1
摘要

The evolutionary processes that drive universal therapeutic resistance in adult patients with diffuse glioma remain unclear1,2. Here we analysed temporally separated DNA-sequencing data and matched clinical annotation from 222 adult patients with glioma. By analysing mutations and copy numbers across the three major subtypes of diffuse glioma, we found that driver genes detected at the initial stage of disease were retained at recurrence, whereas there was little evidence of recurrence-specific gene alterations. Treatment with alkylating agents resulted in a hypermutator phenotype at different rates across the glioma subtypes, and hypermutation was not associated with differences in overall survival. Acquired aneuploidy was frequently detected in recurrent gliomas and was characterized by IDH mutation but without co-deletion of chromosome arms 1p/19q, and further converged with acquired alterations in the cell cycle and poor outcomes. The clonal architecture of each tumour remained similar over time, but the presence of subclonal selection was associated with decreased survival. Finally, there were no differences in the levels of immunoediting between initial and recurrent gliomas. Collectively, our results suggest that the strongest selective pressures occur during early glioma development and that current therapies shape this evolution in a largely stochastic manner.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
wanci应助无限的以亦采纳,获得10
5秒前
糟糕的翅膀完成签到,获得积分10
6秒前
creep2020完成签到,获得积分10
8秒前
谭凯文完成签到 ,获得积分10
15秒前
lorentzh完成签到,获得积分10
32秒前
35秒前
YX完成签到 ,获得积分10
39秒前
41秒前
Sandy应助Am采纳,获得20
48秒前
桐桐应助嘿嘿嘿侦探社采纳,获得10
50秒前
ycool完成签到 ,获得积分10
54秒前
小强完成签到 ,获得积分10
1分钟前
大树完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
1分钟前
1分钟前
2分钟前
naiyantang完成签到 ,获得积分10
2分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
周常通完成签到,获得积分10
2分钟前
2分钟前
xiaosui完成签到 ,获得积分10
3分钟前
lingling完成签到 ,获得积分10
3分钟前
浪麻麻完成签到 ,获得积分10
3分钟前
提提在干嘛完成签到,获得积分10
3分钟前
3分钟前
3分钟前
赧赧完成签到 ,获得积分10
4分钟前
木南完成签到 ,获得积分10
4分钟前
wang完成签到,获得积分10
4分钟前
望向天空的鱼完成签到 ,获得积分10
4分钟前
健康的大船完成签到 ,获得积分10
4分钟前
armpit完成签到,获得积分10
4分钟前
4分钟前
12A完成签到,获得积分10
4分钟前
k001boyxw完成签到,获得积分10
5分钟前
你才是小哭包完成签到 ,获得积分10
5分钟前
酱豆豆完成签到 ,获得积分10
6分钟前
小二郎应助科研通管家采纳,获得10
6分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968521
求助须知:如何正确求助?哪些是违规求助? 3513341
关于积分的说明 11167298
捐赠科研通 3248700
什么是DOI,文献DOI怎么找? 1794417
邀请新用户注册赠送积分活动 875030
科研通“疑难数据库(出版商)”最低求助积分说明 804664