钯
亲核细胞
立体选择性
催化作用
选择性
化学
组合化学
药物化学
有机化学
作者
Huanhuan Luo,Yunfei Zhao,Dawei Wang,Minyan Wang,Zhuangzhi Shi
标识
DOI:10.1016/j.gresc.2020.08.002
摘要
A novel protocol for palladium-catalyzed fluoroarylation of 1,1-difluoroallenes was described here. The reaction proceeded smoothly under mild condition and various trifluoromethylated alkenes were obtained in moderate yields with excellent E selectivity. The mechanism involving a vital trifluoromethylated vinyl silver intermediate, which generated through the F-nucleophilic addition to 1,1-difluoroallenes, has been proposed.
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