细胞外基质
细胞因子
转化生长因子β
转化生长因子
不育
子宫内膜
SMAD公司
生长因子
细胞生物学
间充质干细胞
生物
癌症研究
内科学
内分泌学
医学
免疫学
受体
怀孕
遗传学
作者
Ayitila Abudukeyoumu,Ming‐Qing Li,Feng Xie
摘要
Abstract Intrauterine adhesion (IUA), led by trauma to the basal layer, can prevent the endometrium from growing, resulting in complications in females, such as infertility and amenorrhea. Transforming growth factor‐β1 (TGF‐β1) plays a crucial role in inducing and promoting the differentiation and proliferation of mesenchymal cells, in the secretion of extracellular matrix‐associated components, and is a major cytokine in initiating and terminating tissue repair downstream of the TGF‐β/Smad signaling pathway. Some evidence supports that TGF‐β1 is closely associated with the occurrence and development of IUA, and is regarded as an early risk factor of disease recurrence. Furthermore, the role of TGF‐β1 has been demonstrated to be potentially regulated by a variety of cytokines, hormones, enzymes, and microRNAs. This review provides an overview of the expression, function, and regulation of TGF‐β1 in IUA, with a brief discussion and perspectives on its future clinical implications on the diagnosis and treatment of IUA.
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