Research Progress in Flavonoids as Potential Anticancer Drug Including Synergy with Other Approaches

癌症 植物化学 癌细胞 多重耐药 药理学 抗药性 药代动力学 药品 医学 生物利用度 传统医学 生物 内科学 微生物学
作者
Yusuf Hussain,Suaib Luqman,Abha Meena
出处
期刊:Current Topics in Medicinal Chemistry [Bentham Science Publishers]
卷期号:20 (20): 1791-1809 被引量:21
标识
DOI:10.2174/1568026620666200502005411
摘要

Background: In chemotherapy for cancer, conventional drugs aim to target the rapidly growing and dividing cells at the early stages. However, at an advanced stage, cancer cells become less susceptible because of the multidrug resistance and the recruitment of alternative salvage pathways for their survival. Besides, owing to target non-selectivity, healthy proliferating cells also become vulnerable to the damage. The combination therapies offered using flavonoids to cure cancer not only exert an additive effect against cancer cells by targetting supplementary cell carnage pathways but also hampers the drug resistance mechanisms. Thus, the review aims to discuss the potential and pharmacokinetic limitations of flavonoids in cancer treatment. Further successful synergistic studies reported using flavonoids to treat cancer has been described along with potential drug delivery systems. Methods: A literature search was done by exploring various online databases like Pubmed, Scopus, and Google Scholar with the specific keywords like “Anticancer drugs”, “flavonoids”, “oncology research”, and “pharmacokinetics”. Results: Dietary phytochemicals, mainly flavonoids, hinder cell signalling responsible for multidrug resistance and cancer progression, primarily targeting cancer cells sparing normal cells. Such properties establish flavonoids as a potential candidate for synergistic therapy. However, due to low absorption and high metabolism rates, the bioavailability of flavonoids becomes a challenge. Such challenges may be overcome using novel approaches like derivatization, and single or co-delivery nano-complexes of flavonoids with conventional drugs. These new approaches may improve the pharmacokinetic and pharmacodynamic of flavonoids. Conclusion: This review highlights the application of flavonoids as a potential anticancer phytochemical class in combination with known anti-cancer drugs/nanoparticles. It also discusses flavonoid’s pharmacokinetics and pharmacodynamics issues and ways to overcome such issues. Moreover, it covers successful methodologies employed to establish flavonoids as a safe and effective phytochemical class for cancer treatment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
玺鱼完成签到,获得积分10
1秒前
2秒前
淡淡天蓝完成签到,获得积分10
2秒前
陈美净完成签到,获得积分10
2秒前
科研通AI5应助义气萝卜头采纳,获得10
2秒前
2秒前
3秒前
hsh发布了新的文献求助10
3秒前
杜景婷完成签到 ,获得积分10
4秒前
5秒前
5秒前
mm发布了新的文献求助10
5秒前
6秒前
洋洋麻麻发布了新的文献求助10
7秒前
清脆的雁丝完成签到,获得积分10
7秒前
xn201120发布了新的文献求助10
7秒前
早日毕业发布了新的文献求助10
8秒前
FashionBoy应助独特的苗条采纳,获得10
8秒前
JamesPei应助yuaasusanaann采纳,获得10
8秒前
9秒前
Mason发布了新的文献求助10
10秒前
11秒前
shen完成签到,获得积分10
11秒前
星海梦幻完成签到 ,获得积分10
12秒前
量子星尘发布了新的文献求助10
12秒前
巧稚一生完成签到 ,获得积分10
14秒前
14秒前
15秒前
mm完成签到,获得积分10
17秒前
shen发布了新的文献求助10
17秒前
xphpyy给xphpyy的求助进行了留言
18秒前
hsh完成签到,获得积分10
19秒前
爆米花应助洋洋麻麻采纳,获得10
19秒前
小6s完成签到,获得积分10
20秒前
20秒前
文欣妍完成签到,获得积分10
20秒前
尊敬的飞槐完成签到,获得积分10
20秒前
xn201120发布了新的文献求助10
21秒前
22秒前
淡淡天蓝发布了新的文献求助10
22秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976210
求助须知:如何正确求助?哪些是违规求助? 3520366
关于积分的说明 11203088
捐赠科研通 3256965
什么是DOI,文献DOI怎么找? 1798570
邀请新用户注册赠送积分活动 877738
科研通“疑难数据库(出版商)”最低求助积分说明 806516