Root canal therapy is generally considered to be the most effective way to remove inflammation and infection in the root canal. However, the presence of persistent infection in the root canal may lead to a failure of the treatment. Therefore, the complete removal of root canal infection is essential for the success of root canal therapy. The purpose of root canal therapy is to clear up the intra-canal infection and thoroughly sterilize the root canal, and then fill up the root canal system with dimensionally, so as to prevent reinfection. This article focuses on the main methods and problems of the current root canal infection and the strategy of eradicating the infection in the root canal.根管治疗术被普遍认为是去除根管内炎症及感染的最有效方法。然而,由于根管内持续感染的存在,可能导致治疗失败。因此,彻底清除根管内的感染对根管治疗成功至关重要。根管治疗的目的是清除根管内感染并对根管进行彻底消毒,继而对根管系统进行三维严密的充填,防止再感染。本文着重介绍当前根管内感染清除的主要方法、存在的问题以及根管内感染的控制策略。.