脂肪生成
秀丽隐杆线虫
脂解
脂质代谢
新陈代谢
化学
能量稳态
脂肪酸
β氧化
生物化学
生物
代谢途径
内分泌学
受体
脂肪组织
基因
作者
Renalison Farias‐Pereira,Edward Kim,Yeonhwa Park
出处
期刊:Food Chemistry
[Elsevier]
日期:2020-03-01
卷期号:307: 125537-125537
被引量:23
标识
DOI:10.1016/j.foodchem.2019.125537
摘要
Cafestol, a coffee diterpene, is a known agonist of farnesoid X receptors (FXR), which are involved in cholesterol homeostasis. FXR plays critical roles in other lipid metabolic pathways, including fat oxidation; however, little is known about cafestol's effects on fatty acid metabolism. Thus, the goal was to investigate cafestol's effects on fatty acid metabolism using Caenorhabditis elegans. Cafestol at 60 µM reduced fat accumulation and increased locomotor activity (an indicator of energy expenditure) by 20% and 38%, respectively, compared to the control. Cafestol's effects were dependent on daf-12 (a functional homolog of the human FXR) with upregulation of ech-1.1 (a homolog of enoyl-CoA hydratase involved in fatty acid β-oxidation) and tub-1 (an ortholog of the human TUBBY involved in the neurological regulation of energy expenditure) without any effects on lipogenesis, lipolysis or lipid uptake and transport. Therefore, cafestol increased fat oxidation and energy expenditure via DAF-12-dependent pathway in C. elegans.
科研通智能强力驱动
Strongly Powered by AbleSci AI