As a common uniform shaping device, microlens array is widely used in laser lighting system. ZEMAX software is used to simulate the light path of microlens array unit size, microlens array thickness, microlens array unit curvature radius, adjacent microlens array spacing distance, integral lens focal length change, and to compare and analyze the illumination spot when the above factors change. The results show that: the smaller the size of microlens array unit, the larger the size of illumination spot; the smaller the curvature radius of microlens array unit, the larger the size of illumination spot; the smaller the distance between microlens arrays, the larger the size of illumination spot; the larger the focal length of integral lens, the larger the size of illumination spot. The conclusion provides a basis for the selection of microlens array in lighting system.