Sex Differences in Cortical Morphometry and White Matter Microstructure During Brain Aging and Their Relationships to Cognition

白质 脑老化 心理学 认知 部分各向异性 衰老的大脑 灰色(单位) 磁共振弥散成像 性别特征 人口 脑形态计量学 神经科学 神经影像学 大脑大小 胼胝体 皮质(解剖学) 性二态性 生理学 上纵束 钩束 前额叶皮质 生物 医学 磁共振成像 内分泌学 环境卫生 放射科
作者
Feng Sang,Yunhao Chen,Kewei Chen,Mingxi Dang,Shudan Gao,Zhengwang Zhang
出处
期刊:Cerebral Cortex [Oxford University Press]
卷期号:31 (11): 5253-5262 被引量:3
标识
DOI:10.1093/cercor/bhab155
摘要

Changes in brain structure are associated with aging, and accompanied by the gradual deterioration of cognitive functions, which manifests differently in males and females. Here, we quantify the age-related spatial aging patterns of brain gray and white matter structures, their volume reduction rate, their relationships with specific cognitive functions, as well as differences between males and females in a cross-sectional nondementia dataset. We found that both males and females showed extensive age-related decreases in the volumes of most gray matter and white matter regions. Females have larger regions where the volume decreases with age and a greater slope (females: 0.199%, males: 0.183%) of volume decrease in gray matter. For white matter, no significant sex differences were found in age-related regions, and the slope of volume decrease. More significant associations were identified between brain structures and cognition in males during aging than females. This study explored the age-related regional variations in gray matter and white matter, as well as the sex differences in a nondemented elderly population. This study helps to further understand the aging of the brain structure and sex differences in the aging of brain structures and provides new evidence for the aging of nondemented individuals.
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