白霉素类
抗真菌
抗真菌药
抗真菌药
隐球菌
念珠菌感染
药品
曲霉
生物
曲菌病
抗药性
生物利用度
两性霉素B
药理学
医学
重症监护医学
微生物学
免疫学
卡斯波芬金
作者
Wei Du,Yiru Gao,Li Liu,Sixiang Sai,Chen Ding
标识
DOI:10.3390/ijms221810104
摘要
Fungal infections have become a major health concern, given that invasive infections by Candida, Cryptococcus, and Aspergillus species have led to millions of mortalities. Conventional antifungal drugs including polyenes, echinocandins, azoles, allylamins, and antimetabolites have been used for decades, but their limitations include off-target toxicity, drug-resistance, poor water solubility, low bioavailability, and weak tissue penetration, which cannot be ignored. These drawbacks have led to the emergence of novel antifungal therapies. In this review, we discuss the nanosystems that are currently utilized for drug delivery and the application of antifungal therapies.
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