生物
细胞生物学
信号
肝癌
诱导多能干细胞
癌症研究
转录因子
干细胞
信号转导
癌症
生物信息学
胚胎干细胞
遗传学
基因
作者
Stephanie A. Campbell,Tabea L. Stephan,Jeremy Lotto,Rebecca Cullum,Sibyl Drissler,Pamela A. Hoodless
出处
期刊:Development
[The Company of Biologists]
日期:2021-09-01
卷期号:148 (17)
被引量:9
摘要
Liver development is controlled by key signals and transcription factors that drive cell proliferation, migration, differentiation and functional maturation. In the adult liver, cell maturity can be perturbed by genetic and environmental factors that disrupt hepatic identity and function. Developmental signals and fetal genetic programmes are often dysregulated or reactivated, leading to dedifferentiation and disease. Here, we highlight signalling pathways and transcriptional regulators that drive liver cell development and primary liver cancers. We also discuss emerging models derived from pluripotent stem cells, 3D organoids and bioengineering for improved studies of signalling pathways in liver cancer and regenerative medicine.
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