生长素
血脂异常
肥胖
基因型
基因分型
人口
内科学
内分泌学
血脂谱
医学
生物
多态性(计算机科学)
遗传学
基因
糖尿病
激素
环境卫生
作者
Mehran Yadegari,Reza Zare‐Feyzabadi,Mohanna Zakariaeiseraji,Reza Sahebi,Niloofar Shabani,Hamed Khedmatgozar,Gordon A. Ferns,Hamideh Ghazizadeh,Maryam Mohammadi‐Bajgiran,Melika Jalalian,Mohadese Zoghi,Reza Assaran Darban,Mahdi Mohammadian‐Ghosooni,Habibollah Esmaily,Amir Avan,Majid Ghayour‐Mobarhan
摘要
Abstract In this study, we aimed to investigate the relationship between the genetic variant of rs696217‐ghrelin and fasted lipid profile, indices of obesity, and environmental parameters. Amplification refractory mutation system‐polymerase chain reaction (ARMs‐PCR) was used for genotyping 1118 individuals recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) cohort study. The interaction between the presence of the genetic variant of rs696217‐ghrelin and nutritional intake and other major determinants of obesity and lipid profile was examined in the MASHAD study population. Individuals with the TT genotype at the locus had the lowest prevalence of obesity compared to other genotypes among the individuals. No significant relationship was found between the two groups regarding the lipid profile and TT genotype. Furthermore, no significant association was found between dietary intake and the genetic variant of rs696217‐ghrelin in the population under study. Individuals with a TT or GT genotype appear to be at a higher risk of obesity, compared to those with a GG genotype. The results of the current study revealed a significant association between the genetic variant of rs696217‐ghrelin and obesity; however, this gene did not correlate with the risk factors of cardiovascular diseases and dyslipidemia in the Iranian population.
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