Abstract To explore the fracture characteristics of rock under the interaction of fatigue load and creep load, fatigue–creep interactive loading experiments were performed on red sandstone with prefabricated cracks. The crack evolution process and failure mode were analyzed using acoustic emission technology and digital image correlation. The results showed that crack growth mainly occurred in the fatigue loading stage; the crack evolution of the sample could be divided into three stages: nucleation and initiation ( ), stable expansion ( ), and unstable fracture ( ). There were distinct differences in the crack propagation modes of the rock samples with different prefabricated crack angles. The relationship between the crack initiation angle and prefabricated crack angle was analyzed based on the maximum circumferential stress theory. Moreover, with an increase in the prefabricated crack angle, the rock sample gradually changed from compression–shear failure to tension–shear failure.