Effect of Some Slimming Drugs on Some Biochemical and Physiological Parameters of Albino Rats

Background:The slimming drugs differ in their nature, where apple-lite is a fully natural substance, mirapro-N is a chemical substance and tenuate is a synthetic foamy filler substance. The study aimed to search the physiological and biochemical changes accompanied  with these drugs on rats.  Methods:Forty adult male albino rats (130±20g) were divided into four groups, ten on each treated group and ten for the control one. The  apple-lite group treated with 3.5mg/100 g body weight, the  mirapro-N group treated with 0.14mg/100g body weight and the  tenuate group treated with 0.1 mg/100 g body weight.  Results: The treated  groups showed a significant changes in the lipid and protein profiles, enzymatic activities, in the skin folds and the percentage of body weight compared to the control group.  In conclusion, the slimming drugs showed a change in skin folds thickness  and in percentage of organ’s weight to body weight and also showed a deflection in the investigated biochemical parameters.